Chronic Rhinosinusitis with Nasal Polyps: Age and Disease Severity Differences in the Levels of Inflammatory Markers
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients’ Characteristics
2.2. Determination of Inflammatory Markers Concentration
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristic | CRSwNP N = 59 (53.2%) | Control N = 52 (46.8%) | p Value |
---|---|---|---|
Age, mean ± SD, years | 50.3 ± 14.7 | 45.8 ± 19.5 | 0.177 * |
Age groups, years | |||
18–30 | 5 (8.5) | 15 (28.8) | 0.02 |
31–50 | 22 (37.3) | 16 (30.8) | 0.235 |
>51 | 32 (54.2) | 21 (40.4) | 0.072 |
Sex | |||
Male | 31 (52.5) | 28 (53.8) | 0.891 |
Female | 28 (47.5) | 24 (46.2) | |
Smoking status | |||
Yes | 11 (18.6) | 4 (7.7) | 0.092 |
Allergy | |||
Yes | 15 (25.4) | 0 | <0.001 |
Asthma | |||
Yes | 18 (30.5) | 0 | <0.001 |
Marker, pg/mL | Age Groups, Years | df = 2 χ2; p Value | ||
---|---|---|---|---|
18–30 | 31–50 | >51 | ||
IL-1 | 820.0 (367.7–1576.0) | 1181.6 (864–1489.2) | 1066.0 (719.3–1398.3) | 0.958; 0.619 |
IL-2 | 509.1 (266.8–546.9) | 498.2 (213.1–518.2) | 477.1 (457.5–514.2) | 0.314; 0.855 |
IL-4 | 169.7 (64.5–195.7) | 156.4 (110.5–231.2) | 212.7 (163.7–242.0) | 4.464; 0.107 |
IL-5 | 97.2 (26.1–208.0) | 30.1 (28.2–136.4) | 29.9 (24.1–32.3) | 3.495; 0.174 |
IL-6 | 208.3 (147.1–242.0) | 180.9 (150.3–233.5) | 209.0 (157.5–233.5) | 0.361; 0.835 |
IL-7 | 22.8 (16.4–122.8) | 33.7 (29.4–123.4) | 29.9 (23.1–47.2) | 4.305; 0.116 |
IL-10 | 190.1 (119.0–198.4) | 258.8 (171.4–396.7) | 233.9 (119.0–348.0) | 4.508; 0.105 |
IL-13 | 165.2 (154.5–199.3) | 145.3 (121.4–168.2) | 160.2 (135.9–169.2) | 3.207; 0.201 |
IL-21 | 109.6 (74.6–144.2) | 112.2 * (97.7–118.5) | 92.1* (71.0–105.6) | 6.29; 0.043; * p = 0.013 |
IL-22 | 90.5 (75.1–167.1) | 132.8 (90.5–146.8) | 136.7 (115.5–167.5) | 1.73; 0.421 |
The sum of the SNOT-22 Questionnaire Scores | Interleukins | ||
IL-2 | IL-4 | IL-22 | |
r = 0.464, p < 0.001 | r = 0.502, p < 0.001 | r = 0.521, p < 0.001 |
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Vaitkus, J.; Vitkauskienė, A.; Simuntis, R.; Vaitkus, Ž.; Šiupšinskienė, N.; Vaitkus, S. Chronic Rhinosinusitis with Nasal Polyps: Age and Disease Severity Differences in the Levels of Inflammatory Markers. Medicina 2021, 57, 282. https://doi.org/10.3390/medicina57030282
Vaitkus J, Vitkauskienė A, Simuntis R, Vaitkus Ž, Šiupšinskienė N, Vaitkus S. Chronic Rhinosinusitis with Nasal Polyps: Age and Disease Severity Differences in the Levels of Inflammatory Markers. Medicina. 2021; 57(3):282. https://doi.org/10.3390/medicina57030282
Chicago/Turabian StyleVaitkus, Justinas, Astra Vitkauskienė, Regimantas Simuntis, Žygimantas Vaitkus, Nora Šiupšinskienė, and Saulius Vaitkus. 2021. "Chronic Rhinosinusitis with Nasal Polyps: Age and Disease Severity Differences in the Levels of Inflammatory Markers" Medicina 57, no. 3: 282. https://doi.org/10.3390/medicina57030282