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Does COVID-19 Vaccination Warrant the Classical Principle “ofelein i mi vlaptin”?

Second Medical Clinic, School of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, 54652 Thessaloniki, Greece
Department of Gastroenterology, University Hospital of Larisa, Mezourlo, 41110 Larisa, Greece
Department of Internal Medicine, General Hospital Aghios Pavlos of Thessaloniki, 55134 Thessaloniki, Greece
Second Neonatal Department and NICU, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, Greece
Healthcare Management Program, School of Economics and Management, Open University of Cyprus, Nicosia 2252, Cyprus
Department of Environmental Health, Environmental and Occupational Medicine and Epidemiology (EOME), Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
Nasco AD Biotechnology Laboratory, Department of Research and Development, 18536 Piraeus, Greece
Center for Integrative Psychiatry, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital of Zurich, University of Zurich, 8032 Zurich, Switzerland
Department of Pediatrics, University Children’s Hospital of Zurich, 8032 Zurich, Switzerland
Department of Gastroenterology, 401 Army General Hospital of Athens, 11525 Athens, Greece
Department of Maxillofacial Surgery, 424 General Military Hospital, Ring Road Efkarpia, 56429 Thessaloniki, Greece
ORL and Psychiatry Private Practice, 8032 Zurich, Switzerland
Neurology and Psychiatry Private Practice, 2502 Biel, Switzerland
Alexandrovska University Hospital, Medical University Sofia, 1431 Sofia, Bulgaria
Psychiatric Hospital of Thessaloniki, Stavroupolis, 56429 Thessaloniki, Greece
Department of General, Visceral and Thoracic Surgery, Bürgerspital Solothurn, 4500 Solothurn, Switzerland
General Practitioner, Private Practice, 8032 Zurich, Switzerland
Department of Nuclear Medicine, “Thegeneio” Cancer Hospital, 54007 Thessaloniki, Greece
Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
FOB AKTION, 30002 Aktio, Greece
Author to whom correspondence should be addressed.
Academic Editor: Nicola Luigi Bragazzi
Medicina 2021, 57(3), 253;
Received: 26 January 2021 / Revised: 26 February 2021 / Accepted: 4 March 2021 / Published: 9 March 2021
The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic warrants an imperative necessity for effective and safe vaccination, to restrain Coronavirus disease 2019 (COVID-19) including transmissibility, morbidity, and mortality. In this regard, intensive medical and biological research leading to the development of an arsenal of vaccines, albeit incomplete preconditioned evaluation, due to emergency. The subsequent scientific gap raises some concerns in the medical community and the general public. More specifically, the accelerated vaccine development downgraded the value of necessary pre-clinical studies to elicit medium- and long-term beneficial or harmful consequences. Previous experience and pathophysiological background of coronaviruses’ infections and vaccine technologies, combined with the global vaccines’ application, underlined the obligation of a cautious and qualitative approach, to illuminate potential vaccination-related adverse events. Moreover, the high SARS-CoV-2 mutation potential and the already aggregated genetical alterations provoke a rational vagueness and uncertainty concerning vaccines’ efficacy against dominant strains and the respective clinical immunity. This review critically summarizes existing evidence and queries regarding SARS-CoV-2 vaccines, to motivate scientists’ and clinicians’ interest for an optimal, individualized, and holistic management of this unprecedented pandemic. View Full-Text
Keywords: COVID-19; SARS-COV-2; Hippocrates; ofelein i mi vlaptin; Primum non nocere; vaccine; vaccination COVID-19; SARS-COV-2; Hippocrates; ofelein i mi vlaptin; Primum non nocere; vaccine; vaccination
MDPI and ACS Style

Doulberis, M.; Papaefthymiou, A.; Kotronis, G.; Gialamprinou, D.; Soteriades, E.S.; Kyriakopoulos, A.; Chatzimichael, E.; Kafafyllidou, K.; Liatsos, C.; Chatzistefanou, I.; Anagnostis, P.; Semenin, V.; Ntona, S.; Gkolia, I.; Papazoglou, D.D.; Tsinonis, N.; Papamichos, S.; Kirbas, H.; Zikos, P.; Niafas, D.; Kountouras, J. Does COVID-19 Vaccination Warrant the Classical Principle “ofelein i mi vlaptin”? Medicina 2021, 57, 253.

AMA Style

Doulberis M, Papaefthymiou A, Kotronis G, Gialamprinou D, Soteriades ES, Kyriakopoulos A, Chatzimichael E, Kafafyllidou K, Liatsos C, Chatzistefanou I, Anagnostis P, Semenin V, Ntona S, Gkolia I, Papazoglou DD, Tsinonis N, Papamichos S, Kirbas H, Zikos P, Niafas D, Kountouras J. Does COVID-19 Vaccination Warrant the Classical Principle “ofelein i mi vlaptin”? Medicina. 2021; 57(3):253.

Chicago/Turabian Style

Doulberis, Michael, Apostolis Papaefthymiou, Georgios Kotronis, Dimitra Gialamprinou, Elpidoforos S. Soteriades, Anthony Kyriakopoulos, Eleftherios Chatzimichael, Kyriaki Kafafyllidou, Christos Liatsos, Ioannis Chatzistefanou, Paul Anagnostis, Vitalii Semenin, Smaragda Ntona, Ioanna Gkolia, Dimitrios David Papazoglou, Nikolaos Tsinonis, Spyros Papamichos, Hristos Kirbas, Petros Zikos, Dionisios Niafas, and Jannis Kountouras. 2021. "Does COVID-19 Vaccination Warrant the Classical Principle “ofelein i mi vlaptin”?" Medicina 57, no. 3: 253.

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