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Article

Non-Invasive Analysis of Actinic Keratosis before and after Topical Treatment Using a Cold Stimulation and Near-Infrared Spectroscopy

1
PoliToBIOMed Lab, Biolab, Department of Electronics and Telecommunications, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
2
Dermatology Unit, Department of Health Science, University of Eastern Piedmont, 28100 Novara, Italy
3
Dermatology Unit, Department of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy
*
Author to whom correspondence should be addressed.
Medicina 2020, 56(9), 482; https://doi.org/10.3390/medicina56090482
Received: 17 August 2020 / Revised: 14 September 2020 / Accepted: 18 September 2020 / Published: 21 September 2020
(This article belongs to the Special Issue New Perspectives in the Treatment of Skin Disease)
Background and objectives: The possible evolution of actinic keratoses (AKs) into invasive squamous cell carcinomas (SCC) makes their treatment and monitoring essential. AKs are typically monitored before and after treatment only through a visual analysis, lacking a quantitative measure to determine treatment effectiveness. Near-infrared spectroscopy (NIRS) is a non-invasive measure of the relative change of oxy-hemoglobin and deoxy-hemoglobin (O2Hb and HHb) in tissues. The aim of our study is to determine if a time and frequency analysis of the NIRS signals acquired from the skin lesion before and after a topical treatment can highlight quantitative differences between the AK skin lesion area. Materials and Methods: The NIRS signals were acquired from the skin lesions of twenty-two patients, with the same acquisition protocol: baseline signals, application of an ice pack near the lesion, removal of ice pack and acquisition of vascular recovery. We calculated 18 features from the NIRS signals, and we applied multivariate analysis of variance (MANOVA) to compare differences between the NIRS signals acquired before and after the therapy. Results: The MANOVA showed that the features computed on the NIRS signals before and after treatment could be considered as two statistically separate groups, after the ice pack removal. Conclusions: Overall, the NIRS technique with the cold stimulation may be useful to support non-invasive and quantitative lesion analysis and regression after a treatment. The results provide a baseline from which to further study skin lesions and the effects of various treatments. View Full-Text
Keywords: signal processing; near-infrared spectroscopy; actinic keratosis; field cancerization signal processing; near-infrared spectroscopy; actinic keratosis; field cancerization
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MDPI and ACS Style

Seoni, S.; Savoia, P.; Veronese, F.; Zavattaro, E.; Tarantino, V.; Meiburger, K.M. Non-Invasive Analysis of Actinic Keratosis before and after Topical Treatment Using a Cold Stimulation and Near-Infrared Spectroscopy. Medicina 2020, 56, 482. https://doi.org/10.3390/medicina56090482

AMA Style

Seoni S, Savoia P, Veronese F, Zavattaro E, Tarantino V, Meiburger KM. Non-Invasive Analysis of Actinic Keratosis before and after Topical Treatment Using a Cold Stimulation and Near-Infrared Spectroscopy. Medicina. 2020; 56(9):482. https://doi.org/10.3390/medicina56090482

Chicago/Turabian Style

Seoni, Silvia, Paola Savoia, Federica Veronese, Elisa Zavattaro, Vanessa Tarantino, and Kristen M. Meiburger 2020. "Non-Invasive Analysis of Actinic Keratosis before and after Topical Treatment Using a Cold Stimulation and Near-Infrared Spectroscopy" Medicina 56, no. 9: 482. https://doi.org/10.3390/medicina56090482

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