Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties
Abstract
:1. Introduction
2. Materials and Methods
2.1. Preparation of Yarsagumba (Yarsa) Biomaterial
2.2. Ethics Approval and Consent to Participate
2.3. Isolated Murine Lungs
2.4. Cell isolation, Culture and Proliferation Assay
2.5. Data Analysis
3. Results
3.1. Yarsa Extract Reduced the Proliferation of hPASMCs
3.2. Cordycepin Reduced the Proliferation of hPASMCs
3.3. Yarsa Extract Showed Potent Vasodilatory Properties in Isolated Mouse Lungs
3.4. Cordycepin did not Show any Vasodilatory Properties in Isolated Mouse Lungs
4. Discussion
- (a)
- The application of the whole Yarsagumba extract resulted in significant reduction of hPASMCs proliferation and pulmonary vasodilatation in isolated, buffer-perfused and ventilated mice lungs.
- (b)
- With regard to cordycepin, an active biochemical agent isolated from Yarsagumba, there were also significant anti-proliferative effects on hPASMCs; however, the effects were less prominent in comparison to the whole extract of this parasitic fungus. Finally, there was no visible effect of cordycepin on pulmonary vasoconstriction.
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Share and Cite
Luitel, H.; Novoyatleva, T.; Sydykov, A.; Petrovic, A.; Mamazhakypov, A.; Devkota, B.; Wygrecka, M.; Ghofrani, H.A.; Avdeev, S.; Schermuly, R.T.; et al. Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties. Medicina 2020, 56, 131. https://doi.org/10.3390/medicina56030131
Luitel H, Novoyatleva T, Sydykov A, Petrovic A, Mamazhakypov A, Devkota B, Wygrecka M, Ghofrani HA, Avdeev S, Schermuly RT, et al. Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties. Medicina. 2020; 56(3):131. https://doi.org/10.3390/medicina56030131
Chicago/Turabian StyleLuitel, Himal, Tatyana Novoyatleva, Akylbek Sydykov, Aleksandar Petrovic, Argen Mamazhakypov, Bhuminand Devkota, Malgorzata Wygrecka, Hossein Ardeschir Ghofrani, Sergey Avdeev, Ralph Theo Schermuly, and et al. 2020. "Yarsagumba is a Promising Therapeutic Option for Treatment of Pulmonary Hypertension due to the Potent Anti-Proliferative and Vasorelaxant Properties" Medicina 56, no. 3: 131. https://doi.org/10.3390/medicina56030131