Primary Melanoma of the Lung: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy, Eligibility Criteria and Study Selection
2.2. Statistical Analysis and Reporting
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Marker | Cases Tested, n | Positive Staining, n (%) | Negative Staining, n (%) |
---|---|---|---|
S-100 | 55 | 51 (92.7) | 4 (7.3) |
HMB 45 | 53 | 50 (94.3) | 3 (5.7) |
Cytokeratin | 38 | 0 (0) | 38 (100) |
Melan-A | 21 | 18 (85.7) | 3 (14.3) |
Chromorganin | 17 | 0 (0) | 17 (100) |
CAM 5.2 | 13 | 1 (7.7) | 12 (92.3) |
AE1/AE3 | 12 | 1 (8.3) | 11 (91.7) |
Vimentin | 11 | 9 (81.8) | 2 (18.2) |
CEA | 10 | 3 (30) | 7 (70) |
NSE | 5 | 1 (20) | 4 (80) |
Treatment | No (%) |
---|---|
Surgery (case with available data) | 72 |
Total patients who underwent surgery | 51 (70.8) |
Total surgical procedures | 56 |
Lobectomy | 35 (62.5) |
Wedge resection | 11 (19.6) |
Pneumonectomy | 7 (12.5) |
Broncoscopic resection | 2 (3.6) |
Other/NA | 1 (1.8) |
Chemotherapy (cases with available data) | 34 |
Total patients treated | 20 (58.8) |
Dacarbazine | 5 (25) |
Dacarbazine, vincristine, nimustine | 3 (15) |
Carboplatin | 1 (5) |
Paclitaxel | 1 (5) |
Vindesine, temozolomide, dacarbazine, carboplatin | 1 (5) |
Other/NA | 1 (5) |
Radiotherapy | 8 |
Other therapies | 14 |
Immunotherapy | 5 (35.7) |
Interferon | 2 (14.3) |
Interferon + immunotherapy | 2 (14.3) |
Supportive care | 3 (21.4) |
Targeted therapy + immunotherapy | 1 (7.1) |
Other/NA | 1 (7.1) |
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Paliogiannis, P.; Fara, A.M.; Pintus, G.; Abdel-Rahman, W.M.; Colombino, M.; Casula, M.; Palmieri, G.; Cossu, A. Primary Melanoma of the Lung: A Systematic Review. Medicina 2020, 56, 576. https://doi.org/10.3390/medicina56110576
Paliogiannis P, Fara AM, Pintus G, Abdel-Rahman WM, Colombino M, Casula M, Palmieri G, Cossu A. Primary Melanoma of the Lung: A Systematic Review. Medicina. 2020; 56(11):576. https://doi.org/10.3390/medicina56110576
Chicago/Turabian StylePaliogiannis, Panagiotis, Antonella M. Fara, Gianfranco Pintus, Wael M. Abdel-Rahman, Maria Colombino, Milena Casula, Giuseppe Palmieri, and Antonio Cossu. 2020. "Primary Melanoma of the Lung: A Systematic Review" Medicina 56, no. 11: 576. https://doi.org/10.3390/medicina56110576