Impact of microsatellite instability on survival of endometrial cancer patients
Abstract
Materials and methods: We examined MSI status and survival of 109 women. MSI was detected by employing the Promega MSI Analysis System, which used 5 mononucleotides markers (BAT-25, BAT-26, NR-21, NR-24, and MONO-27) to identify MSI in a tumor and normal tissue DNA and 2 pentanucleotide markers (Penta C and Penta D) for specimen identification. Median follow-up of patients was 40.4 months (range 5.2–47.9). Survival was estimated by the Kaplan–Meier method and Cox regression analysis was used to assess the effects of different variables on patient survival.
Results: MSI-high was detected in 15.6% EC cases, all of which were associated with endometrioid type histology. Kaplan–Meier survival analysis showed no statistically significant differences between patients with MSI-high and MSI stable tumors (P = 0.4) and multivariate analysis concluded that MSI status remained insignificant after stage, histology and tumor grade adjustment (P = 0.5).
Conclusions: Our study showed no statistically significant relationship between MSI-high and survival of endometrial cancer patients.
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Kanopienė, D.; Smailytė, G.; Vidugirienė, J.; Bacher, J. Impact of microsatellite instability on survival of endometrial cancer patients. Medicina 2014, 50, 216-221. https://doi.org/10.1016/j.medici.2014.09.002
Kanopienė D, Smailytė G, Vidugirienė J, Bacher J. Impact of microsatellite instability on survival of endometrial cancer patients. Medicina. 2014; 50(4):216-221. https://doi.org/10.1016/j.medici.2014.09.002
Chicago/Turabian StyleKanopienė, Daiva, Giedrė Smailytė, Jolanta Vidugirienė, and Jeff Bacher. 2014. "Impact of microsatellite instability on survival of endometrial cancer patients" Medicina 50, no. 4: 216-221. https://doi.org/10.1016/j.medici.2014.09.002