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Gliomatosis cerebri

Rymantė Gleiznienė
Ugnius Bučinskas
Saulius Lukoševičius
Antanas Vaitkus
Simona Letautienė
Daiva Apanavičiūtė
1 and
Milda Galvonaitė
Department of Radiology, Kaunas University of Medicine
Department of Neurology, Kaunas University of Medicine
Vilnius Oncology Hospital, Lithuania
Author to whom correspondence should be addressed.
Medicina 2010, 46(5), 341;
Submission received: 16 April 2009 / Accepted: 7 May 2010 / Published: 12 May 2010


Gliomatosis cerebri is a rare diffusely infiltrating glial tumor involving two or more lobes and is frequently is bilateral. Infiltrative extent of tumor is out of proportion to histological and clinical features. We present a case in which finally the diagnosis of gliomatosis cerebri was made. In this case, computed tomography showed that midline structures were insignificantly shifted to the left, there was a mild dilatation of lateral ventricles more expressed on the right, and no pathologic changes of brain tissue density were found. On magnetic resonance tomography, T2W/SE and T2W/FLAIR images revealed zones of hyperintense signal, spreading with time, through several lobes of the brain with no enhancement on T1W images. Diagnosis of gliomatosis cerebri was suspected, stereotaxic biopsy was performed, and pathological examination revealed changes typical of diffuse glial tumor. In this article, changes typical of gliomatosis cerebri seen in other radiological methods such as computed tomography, magnetic resonance spectroscopy, dynamic contrast-enhanced T2*-weighted magnetic resonance, and positron emission tomography also are discussed.
Keywords: gliomatosis cerebri; magnetic resonance tomography; stereotaxic biopsy gliomatosis cerebri; magnetic resonance tomography; stereotaxic biopsy

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MDPI and ACS Style

Gleiznienė, R.; Bučinskas, U.; Lukoševičius, S.; Vaitkus, A.; Letautienė, S.; Apanavičiūtė, D.; Galvonaitė, M. Gliomatosis cerebri. Medicina 2010, 46, 341.

AMA Style

Gleiznienė R, Bučinskas U, Lukoševičius S, Vaitkus A, Letautienė S, Apanavičiūtė D, Galvonaitė M. Gliomatosis cerebri. Medicina. 2010; 46(5):341.

Chicago/Turabian Style

Gleiznienė, Rymantė, Ugnius Bučinskas, Saulius Lukoševičius, Antanas Vaitkus, Simona Letautienė, Daiva Apanavičiūtė, and Milda Galvonaitė. 2010. "Gliomatosis cerebri" Medicina 46, no. 5: 341.

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