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Article

Hesperetin-7-O-Glucuronide Improves Endothelial Cell Function Through Improving NO/ET-1 Balance and Reducing Oxidative Stress via miRNAs

by
Lu Li
*,
Kexin Ji
,
Fengqi Du
,
Nini Jin
,
He Li
and
Xinqi Liu
*
Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China
*
Authors to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2026, 48(5), 538; https://doi.org/10.3390/cimb48050538
Submission received: 1 April 2026 / Revised: 12 May 2026 / Accepted: 13 May 2026 / Published: 21 May 2026
(This article belongs to the Special Issue Biologically Active Compounds: Sources, Mechanisms of Action, and Applications)
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Abstract

Citrus flavonoid intake is associated with beneficial effects on endothelial function. Our previous randomized control trial demonstrated that the concentration of Hesperetin-7-O-glucuronide (H7G) was positively correlated with the improvement in endothelial function in overweight and obese participants following blood orange juice consumption. To explore the underlying mechanism by which H7G improves endothelial function, we investigated the regulation of H7G on endothelial function in a permanent human endothelial cell line (EA. hy926 cells) under normal and oxidative conditions treated with high-oxidation low-density lipoprotein. The results indicated that H7G improved the expression of nitric oxide synthase 3 (NOS3), heme oxygenase 1 (HMOX1) ad glutamate cysteine ligase catalytic (GCLC), and inhibited the expression of endothelin-1 (EDN1), through the upregulation of miR-660-5p and inhibition of miR-21-5p. In summary, H7G improves endothelial cell function via the upregulation of miR-660-5p and the inhibition of miR-21-5p.
Keywords: Hesperetin-7-O-glucuronide; endothelial function; oxidative stress; NO/ET-1; miRNAs Hesperetin-7-O-glucuronide; endothelial function; oxidative stress; NO/ET-1; miRNAs

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MDPI and ACS Style

Li, L.; Ji, K.; Du, F.; Jin, N.; Li, H.; Liu, X. Hesperetin-7-O-Glucuronide Improves Endothelial Cell Function Through Improving NO/ET-1 Balance and Reducing Oxidative Stress via miRNAs. Curr. Issues Mol. Biol. 2026, 48, 538. https://doi.org/10.3390/cimb48050538

AMA Style

Li L, Ji K, Du F, Jin N, Li H, Liu X. Hesperetin-7-O-Glucuronide Improves Endothelial Cell Function Through Improving NO/ET-1 Balance and Reducing Oxidative Stress via miRNAs. Current Issues in Molecular Biology. 2026; 48(5):538. https://doi.org/10.3390/cimb48050538

Chicago/Turabian Style

Li, Lu, Kexin Ji, Fengqi Du, Nini Jin, He Li, and Xinqi Liu. 2026. "Hesperetin-7-O-Glucuronide Improves Endothelial Cell Function Through Improving NO/ET-1 Balance and Reducing Oxidative Stress via miRNAs" Current Issues in Molecular Biology 48, no. 5: 538. https://doi.org/10.3390/cimb48050538

APA Style

Li, L., Ji, K., Du, F., Jin, N., Li, H., & Liu, X. (2026). Hesperetin-7-O-Glucuronide Improves Endothelial Cell Function Through Improving NO/ET-1 Balance and Reducing Oxidative Stress via miRNAs. Current Issues in Molecular Biology, 48(5), 538. https://doi.org/10.3390/cimb48050538

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