A Clinical Case of Multisystem Inflammatory Syndrome After SARS-CoV-2 Infection Associated with Group A β-Hemolytic Streptococcus Coinfection and Venous Thrombosis in a Child with Congenital Thrombophilia
Abstract
1. Introduction
2. Case Report
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Normal Ranges | Day 1 * | Day 3 | Day 5 ** | Day 7 | |
---|---|---|---|---|---|
White blood count | 5.5–15.5 × 109/L | 37.43 | 19.26 | 24.99 | 25.79 |
Lymphocytes | 29–65% | 3.4 | 17.1 | 15.5 | 17.7 |
Neutrophils | 30–60% | 94.5 | 76.4 | 82.1 | 79.9 |
Red blood count | 3.9–5.1 × 1012/L | 4.51 | 3.06 | 3.57 | 3.76 |
Hemoglobin | 111–143 g/L | 114 | 75 | 87 | 93 |
Platelets | 286–509 × 109/L | 82 | 74 | 430 | 633 |
Erythrocyte sedimentation rate | 1–18 mm/h | 35 | – | – | 30 |
C-reactive protein | 0–5 mg/L | 503.27 | >200 | 20.4 | 20.5 |
Procalcitonin | <0.1 ng/mL | 42.29 | – | 14.58 | 0.3 |
Ferritin | 4.4–64 ng/mL | 8494.2 | 667 | – | 509 |
Uric acid | 0–420 µmol/L | 610 | 289 | – | 256 |
Albumin | 38–54 g/L | 31.99 | – | – | 35.77 |
Troponin I | 0–1 ng/mL | <0.01 | 0.011 | 0.003 | <0.01 |
NT-pro BNP | <300 pg/mL | 9105 | 1357 | 420 | 302 |
ASAT | <50 U/L | 159 | – | – | 15 |
ALAT | <36 U/L | 64 | – | – | 12 |
LDH | 120–300 U/L | 975 | 284 | – | 324 |
Antistreptolysin O titer | 0–150 IU/mL | 6.16 | – | – | 178.52 |
Fibrinogen | 200–400 mg/dL | 354 | 274 | – | 314 |
D-dimer | <500 ng/mL | >3000 | 2878 | 1895 | 936.5 |
aPTT | 28–34 s | 47.4 | 24.3 | 24.7 | 25.9 |
INR | 0.9–1.2 | 2.06 | 1.37 | 1.28 | 1.07 |
Prothrombin time | 11–14 s | 27 | 18.7 | 17 | 12.7 |
SARS-CoV-2 IgM/IgA | >0.6 BAU/mL | 1.78 | – | – | – |
SARS-CoV-2 IgG | >1.6 BAU/mL | 8.4 | – | – | – |
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Stoyanova, Z.; Temelkova, K.; Ganeva, M.; Vasilev, T.; Dasheva-Dimitrova, A.; Kibarova-Hristova, D.; Stefanov, S. A Clinical Case of Multisystem Inflammatory Syndrome After SARS-CoV-2 Infection Associated with Group A β-Hemolytic Streptococcus Coinfection and Venous Thrombosis in a Child with Congenital Thrombophilia. Curr. Issues Mol. Biol. 2025, 47, 334. https://doi.org/10.3390/cimb47050334
Stoyanova Z, Temelkova K, Ganeva M, Vasilev T, Dasheva-Dimitrova A, Kibarova-Hristova D, Stefanov S. A Clinical Case of Multisystem Inflammatory Syndrome After SARS-CoV-2 Infection Associated with Group A β-Hemolytic Streptococcus Coinfection and Venous Thrombosis in a Child with Congenital Thrombophilia. Current Issues in Molecular Biology. 2025; 47(5):334. https://doi.org/10.3390/cimb47050334
Chicago/Turabian StyleStoyanova, Zdravka, Katya Temelkova, Margarita Ganeva, Teodor Vasilev, Anna Dasheva-Dimitrova, Desislava Kibarova-Hristova, and Stefan Stefanov. 2025. "A Clinical Case of Multisystem Inflammatory Syndrome After SARS-CoV-2 Infection Associated with Group A β-Hemolytic Streptococcus Coinfection and Venous Thrombosis in a Child with Congenital Thrombophilia" Current Issues in Molecular Biology 47, no. 5: 334. https://doi.org/10.3390/cimb47050334
APA StyleStoyanova, Z., Temelkova, K., Ganeva, M., Vasilev, T., Dasheva-Dimitrova, A., Kibarova-Hristova, D., & Stefanov, S. (2025). A Clinical Case of Multisystem Inflammatory Syndrome After SARS-CoV-2 Infection Associated with Group A β-Hemolytic Streptococcus Coinfection and Venous Thrombosis in a Child with Congenital Thrombophilia. Current Issues in Molecular Biology, 47(5), 334. https://doi.org/10.3390/cimb47050334