Next Article in Journal
Genome-Wide Identification and Analysis of the JAZ Gene Family in Artemisia argyi
Previous Article in Journal
Dose-Dependent PFESA-BP2 Exposure Increases Risk of Liver Toxicity and Hepatocellular Carcinoma
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
CIMB
Volume 47
Issue 2
10.3390/cimb47020099
cimb-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

The Role of Ferroptosis and Cuproptosis in Tuberculosis Pathogenesis: Implications for Therapeutic Strategies

by
John Dawi
1,
Stephen Affa
2,
Kevin Kafaja
1,
Yura Misakyan
1,
Samuel Kades
1,
Surbi Dayal
1,
Sabrina Fardeheb
1,
Ananya Narasimhan
1,
Kevin Tumanyan
3 and
Vishwanath Venketaraman
1,*
1
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA
2
Department of Chemistry, Physics, and Engineering, Los Angeles Valley College, Valley Glen, CA 91401, USA
3
College of Podiatric Medicine, Western University of Health Sciences, Pomona, CA 91766, USA
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2025, 47(2), 99; https://doi.org/10.3390/cimb47020099
Submission received: 31 December 2024 / Revised: 28 January 2025 / Accepted: 1 February 2025 / Published: 5 February 2025
(This article belongs to the Section Molecular Medicine)
Browse Figures
Versions Notes

Abstract

Tuberculosis (TB) caused by Mycobacterium tuberculosis (M.tb) remains a global health crisis, with over 10 million people affected annually. Despite advancements in treatment, M.tb has developed mechanisms to evade host immune responses, complicating efforts to eradicate the disease. Two emerging cell death pathways, ferroptosis and cuproptosis, have been linked to TB pathogenesis. Ferroptosis, an iron-dependent form of cell death, is driven by lipid peroxidation and reactive oxygen species (ROS) accumulation. This process can limit M.tb replication by depleting intracellular iron and inducing macrophage necrosis. However, excessive ferroptosis may lead to tissue damage and aid bacterial dissemination. Cuproptosis, triggered by copper accumulation, disrupts mitochondrial metabolism, leading to protein aggregation and cell death. M.tb exploits both iron and copper metabolism to survive within macrophages, manipulating these processes to resist oxidative stress and immune responses. This review examines the roles of ferroptosis and cuproptosis in TB, discussing how M.tb manipulates these pathways for survival. While therapeutic strategies targeting these processes, such as ferroptosis inducers (Erastin, RSL3) and inhibitors (Ferrostatin-1) and copper ionophores (Disulfiram, Elesclomol) and chelators, show promise, the limited understanding of these pathways and potential off-target effects remains a significant challenge. Further exploration of these pathways may provide insights into the development of targeted therapies aimed at controlling M.tb infection while minimizing host tissue damage. By elucidating the complex interactions between ferroptosis, cuproptosis, and TB, future therapies could better address bacterial resistance and improve clinical outcomes.
Keywords: ferroptosis; cuproptosis; tuberculosis; oxidative stress; M.tb; macrophage ferroptosis; cuproptosis; tuberculosis; oxidative stress; M.tb; macrophage

Share and Cite

MDPI and ACS Style

Dawi, J.; Affa, S.; Kafaja, K.; Misakyan, Y.; Kades, S.; Dayal, S.; Fardeheb, S.; Narasimhan, A.; Tumanyan, K.; Venketaraman, V. The Role of Ferroptosis and Cuproptosis in Tuberculosis Pathogenesis: Implications for Therapeutic Strategies. Curr. Issues Mol. Biol. 2025, 47, 99. https://doi.org/10.3390/cimb47020099

AMA Style

Dawi J, Affa S, Kafaja K, Misakyan Y, Kades S, Dayal S, Fardeheb S, Narasimhan A, Tumanyan K, Venketaraman V. The Role of Ferroptosis and Cuproptosis in Tuberculosis Pathogenesis: Implications for Therapeutic Strategies. Current Issues in Molecular Biology. 2025; 47(2):99. https://doi.org/10.3390/cimb47020099

Chicago/Turabian Style

Dawi, John, Stephen Affa, Kevin Kafaja, Yura Misakyan, Samuel Kades, Surbi Dayal, Sabrina Fardeheb, Ananya Narasimhan, Kevin Tumanyan, and Vishwanath Venketaraman. 2025. "The Role of Ferroptosis and Cuproptosis in Tuberculosis Pathogenesis: Implications for Therapeutic Strategies" Current Issues in Molecular Biology 47, no. 2: 99. https://doi.org/10.3390/cimb47020099

APA Style

Dawi, J., Affa, S., Kafaja, K., Misakyan, Y., Kades, S., Dayal, S., Fardeheb, S., Narasimhan, A., Tumanyan, K., & Venketaraman, V. (2025). The Role of Ferroptosis and Cuproptosis in Tuberculosis Pathogenesis: Implications for Therapeutic Strategies. Current Issues in Molecular Biology, 47(2), 99. https://doi.org/10.3390/cimb47020099

Article Metrics

Back to TopTop