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Volume 47
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10.3390/cimb47010006
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Review

Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions

by
Hyeon-Jeong Hwang
†,
Youngsang Nam
†,
Chanhee Jang
,
Eun La Kim
,
Eun Seo Jang
,
Yeo Jin Lee
and
Seoung Rak Lee
*
College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2025, 47(1), 6; https://doi.org/10.3390/cimb47010006
Submission received: 24 November 2024 / Revised: 22 December 2024 / Accepted: 24 December 2024 / Published: 26 December 2024
(This article belongs to the Special Issue Phytochemicals in Cancer Chemoprevention and Treatment)
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Abstract

Cancer remains a significant medical challenge, necessitating the discovery of novel therapeutic agents. Ribosomally synthesized and post-translationally modified peptides (RiPPs) from plants have emerged as a promising source of anticancer compounds, offering unique structural diversity and potent biological activity. This review identifies and discusses cytotoxic RiPPs across various plant families, focusing on their absolute chemical structures and reported cytotoxic activities against cancer cell lines. Notably, plant-derived RiPPs such as rubipodanin A and mallotumides A–C demonstrated low nanomolar IC50 values against multiple cancer cell types, highlighting their therapeutic potential. By integrating traditional ethnobotanical knowledge with modern genomic and bioinformatic approaches, this study underscores the importance of plant RiPPs as a resource for developing innovative cancer treatments. These findings pave the way for further exploration of plant RiPPs, emphasizing their role in addressing the ongoing challenges in oncology and enhancing the repertoire of effective anticancer therapies.
Keywords: phytochemicals; ribosomally synthesized and post-translationally modified peptides; chemical structure; anticancer activity; biosynthesis phytochemicals; ribosomally synthesized and post-translationally modified peptides; chemical structure; anticancer activity; biosynthesis

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MDPI and ACS Style

Hwang, H.-J.; Nam, Y.; Jang, C.; Kim, E.L.; Jang, E.S.; Lee, Y.J.; Lee, S.R. Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions. Curr. Issues Mol. Biol. 2025, 47, 6. https://doi.org/10.3390/cimb47010006

AMA Style

Hwang H-J, Nam Y, Jang C, Kim EL, Jang ES, Lee YJ, Lee SR. Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions. Current Issues in Molecular Biology. 2025; 47(1):6. https://doi.org/10.3390/cimb47010006

Chicago/Turabian Style

Hwang, Hyeon-Jeong, Youngsang Nam, Chanhee Jang, Eun La Kim, Eun Seo Jang, Yeo Jin Lee, and Seoung Rak Lee. 2025. "Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions" Current Issues in Molecular Biology 47, no. 1: 6. https://doi.org/10.3390/cimb47010006

APA Style

Hwang, H.-J., Nam, Y., Jang, C., Kim, E. L., Jang, E. S., Lee, Y. J., & Lee, S. R. (2025). Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions. Current Issues in Molecular Biology, 47(1), 6. https://doi.org/10.3390/cimb47010006

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