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Phytochemical Modulators of Mitochondria: The Search for Chemopreventive Agents and Supportive Therapeutics

Department of Food Biotechnology, Faculty of Food Technology, University of Agriculture, ul. Balicka 122, 30-149 Krakow, Poland
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Pharmaceuticals 2014, 7(9), 913-942; https://doi.org/10.3390/ph7090913
Received: 15 July 2014 / Revised: 31 July 2014 / Accepted: 13 August 2014 / Published: 4 September 2014
(This article belongs to the Special Issue Mitochondrial Target-Based Drug Discovery)
Mitochondria are crucially important for maintaining not only the energy homeostasis, but the proper cellular functions in a general sense. Impairment of mitochondrial functions is observed in a broad variety of pathological states such as neoplastic transformations and cancer, neurodegenerative diseases, metabolic disorders and chronic inflammation. Currently, in parallel to the classical drug design approaches, there is an increasing interest in the screening for natural bioactive substances, mainly phytochemicals, in order to develop new therapeutic solutions for the mentioned pathologies. Dietary phytochemicals such as resveratrol, curcumin and sulforaphane are very well tolerated and can effectively complement classical pharmacological therapeutic regimens. In this paper we disscuss the effect of the chosen phytochemicals (e.g., resveratrol, curcumin, sulforaphane) on various aspects of mitochondrial biology, namely mitochondrial biogenesis, membrane potential and reactive oxygen species production, signaling to and from the nucleus and unfolded protein response. View Full-Text
Keywords: resveratrol; curcumin; sulforaphane; respiration; retrograde and anterograde signaling; longevity; cancer resveratrol; curcumin; sulforaphane; respiration; retrograde and anterograde signaling; longevity; cancer
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Grabacka, M.M.; Gawin, M.; Pierzchalska, M. Phytochemical Modulators of Mitochondria: The Search for Chemopreventive Agents and Supportive Therapeutics. Pharmaceuticals 2014, 7, 913-942.

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