Next Article in Journal
Sphingosine 1-Phosphate Receptor 1 as a Useful Target for Treatment of Multiple Sclerosis
Next Article in Special Issue
A Review of Therapeutic Aptamer Conjugates with Emphasis on New Approaches
Previous Article in Journal
Biochemical Traits, Survival and Biological Properties of the Probiotic Lactobacillus plantarum Grown in the Presence of Prebiotic Inulin and Pectin as Energy Source
Previous Article in Special Issue
Anti-HCV RNA Aptamers Targeting the Genomic cis-Acting Replication Element
Article Menu

Export Article

Open AccessReview
Pharmaceuticals 2012, 5(5), 493-513;

Selecting Molecular Recognition. What Can Existing Aptamers Tell Us about Their Inherent Recognition Capabilities and Modes of Interaction?

Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
Author to whom correspondence should be addressed.
Received: 5 March 2012 / Revised: 19 April 2012 / Accepted: 10 May 2012 / Published: 18 May 2012
(This article belongs to the Special Issue Aptamer-Based Therapeutics)
Full-Text   |   PDF [959 KB, uploaded 18 May 2012]   |  


The use of nucleic acid derived aptamers has rapidly expanded since the introduction of SELEX in 1990. Nucleic acid aptamers have demonstrated their ability to target a broad range of molecules in ways that rival antibodies, but advances have been very uneven for different biochemical classes of targets, and clinical applications have been slow to emerge. What sets different aptamers apart from each other and from rivaling molecular recognition platforms, specifically proteins? What advantages do aptamers as a reagent class offer, and how do the chemical properties and selection procedures of aptamers influence their function? Do the building blocks of nucleic acid aptamers dictate inherent limitations in the nature of molecular targets, and do existing aptamers give us insight in how these challenges might be overcome? This review is written as an introduction for potential endusers of aptamer technology who are evaluating the advantages of aptamers as a versatile, affordable, yet highly expandable platform to target a broad range of biological processes or interactions. View Full-Text
Keywords: aptamers; molecular recognition; nucleic acids aptamers; molecular recognition; nucleic acids

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Zhang, Q.; Landgraf, R. Selecting Molecular Recognition. What Can Existing Aptamers Tell Us about Their Inherent Recognition Capabilities and Modes of Interaction? Pharmaceuticals 2012, 5, 493-513.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top