Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates
1
Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
2
Center for Clinical Pharmacology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
3
Department of Pediatric Cardiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(2), 393-405; https://doi.org/10.3390/ph3020393
Received: 24 November 2009 / Revised: 15 January 2010 / Accepted: 21 January 2010 / Published: 3 February 2010
(This article belongs to the Special Issue Non-Steroidal Anti-Inflammatory Drugs)
Non-steroidal anti-inflammatory drugs like ibuprofen or indomethacin are commonly prescribed drugs to induce pharmacologic closure of a patent ductus arteriosus in preterm neonates. Based on a recently published Cochrane meta-analysis, both drugs are equally effective to induce closure. Drug choice can therefore be based on differences in side effects or pharmaco-economic arguments. The current review quantifies the negative impact of either ibuprofen or indomethacin on renal function, including diuresis, glomerular filtration rate and renal tubular function. Both ibuprofen and indomethacin have a quantifiable impact on renal function. However, compared to ibuprofen, the negative impact of indomethacin is more pronounced.
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MDPI and ACS Style
Allegaert, K.; De Hoon, J.; Debeer, A.; Gewillig, M. Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates. Pharmaceuticals 2010, 3, 393-405.
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