Synthesis of Amino-gem-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds

Ordoñez, Mario; Argüello Velasco, Rubén Oswaldo

doi:10.3390/ph18071063

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Synthesis of Amino-gem-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds

by

Mario Ordoñez

^1,*

and

Rubén Oswaldo Argüello Velasco

^2,*

¹

Centro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca 62209, Morelos, Mexico

²

Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca 62209, Morelos, Mexico

^*

Authors to whom correspondence should be addressed.

Pharmaceuticals 2025, 18(7), 1063; https://doi.org/10.3390/ph18071063

Submission received: 18 June 2025 / Revised: 11 July 2025 / Accepted: 16 July 2025 / Published: 18 July 2025

(This article belongs to the Special Issue The Pharmacology of Bisphosphonates: New Advances)

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Abstract

In recent years, amino-gem-bisphosphonic acids and their esters have been considered a family of compounds of great chemical and pharmacological interest due to their important biological properties and their value as key synthons in the synthesis of more complex molecules with biological interest. This explains why several research groups are interested in developing new methods for the preparation of these compounds. Therefore, we would like to report here a summary of the synthetic strategies published in the last fifteen years for the synthesis of acyclic and heterocyclic α-, β- and γ-amino-gem-bisphosphonates, as well as their application in the preparation of selected compounds of chemical and pharmacological interest. This information can be of general knowledge to researchers working in this area, as it provides the starting point for new methods and applications of these compounds.

Keywords: synthesis of amino-gem-bisphosphonates; synthesis of amino-gem-bisphosphonic acids; biological activity of amino-gem-bisphosphonates

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MDPI and ACS Style

Ordoñez, M.; Argüello Velasco, R.O. Synthesis of Amino-gem-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds. Pharmaceuticals 2025, 18, 1063. https://doi.org/10.3390/ph18071063

AMA Style

Ordoñez M, Argüello Velasco RO. Synthesis of Amino-gem-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds. Pharmaceuticals. 2025; 18(7):1063. https://doi.org/10.3390/ph18071063

Chicago/Turabian Style

Ordoñez, Mario, and Rubén Oswaldo Argüello Velasco. 2025. "Synthesis of Amino-gem-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds" Pharmaceuticals 18, no. 7: 1063. https://doi.org/10.3390/ph18071063

APA Style

Ordoñez, M., & Argüello Velasco, R. O. (2025). Synthesis of Amino-gem-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds. Pharmaceuticals, 18(7), 1063. https://doi.org/10.3390/ph18071063

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Synthesis of Amino-gem-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds

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