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Volume 18
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Emulgel with Origanum vulgare L. Oil: A New Therapeutic Proposal in Case of Dermal Bacterial Infections

by
Mariana Ganea
1,†,
Diana Constanța Pelea
2,†,
Florina (Miere) Groza
2,*,
Octavia Gligor
2,
Laura Grațiela Vicaș
1,*,
Marcel Zdrîncă
3,4,
Antonia Maria Lestyan
2,
Marieta Lestyan
2,
Ionuț Daniel Venter
5,
Mădalin Florin Ganea
6,
Laura Maghiar
4,7,
Timea Claudia Ghitea
1 and
Corina Moisa
1
1
Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410028 Oradea, Romania
2
Preclinic Department, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410028 Oradea, Romania
3
Surgical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410028 Oradea, Romania
4
Clinical County Emergency Hospital Oradea, 65 Gh.Doja Street, 410169 Oradea, Romania
5
Doctoral School of Biomedical Sciences, University of Oradea, 1 Universitătii Street, 410073 Oradea, Romania
6
Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, 410028 Oradea, Romania
7
Psychoneuroscience and Recovery Department, University of Oradea, 1st Decembrie Street, 410028 Oradea, Romania
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceuticals 2025, 18(11), 1768; https://doi.org/10.3390/ph18111768
Submission received: 18 October 2025 / Revised: 9 November 2025 / Accepted: 18 November 2025 / Published: 20 November 2025
(This article belongs to the Section Natural Products)
Review Reports Versions Notes

Abstract

Background: The treatment of bacterial dermatological diseases is currently facing major difficulties, determined by the alarming increase in the resistance of pathogenic bacteria to conventional therapies. In this context, a viable and effective alternative is represented by the use of phytocompounds to obtain the desired therapeutic effect. The essential oil of Origanum vulgare L. stands out for its antibacterial, anti-aging, collagen synthesis stimulating and wound healing properties. However, its use is limited by certain disadvantages, such as poor stability and the risk of skin irritation due to accumulation in the dermis. Method: The process of formulating the emulgel with oregano oil respected the specific technological steps. The resulting emulgel was subjected to a series of tests, including organoleptic, stability and antimicrobial efficacy determinations. In addition, an in vivo study was conducted to confirm the lack of irritation, involving six groups of patients differentiated by age, sex and skin phenotype. Results: The test results revealed that the emulgel formulated with oregano oil is stable, has organoleptic properties and an appropriate pH for topical use. The product demonstrated antibacterial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa. In addition, short-term in vivo tests (20 min—96 h) confirmed the safety and absence of skin irritation, indicating its potential as an effective alternative treatment. Conclusions: In conclusion, the emulgel with origanum oil represents an innovative formulation for topical application. The product is well tolerated by the skin and does not cause irritation, and its antibacterial properties validate it as a promising therapeutic solution.
Keywords: Origanum vulgare L. oil; emulgel formulation; antimicrobial capacity; cutaneous reaction; in vivo testing Origanum vulgare L. oil; emulgel formulation; antimicrobial capacity; cutaneous reaction; in vivo testing

Share and Cite

MDPI and ACS Style

Ganea, M.; Pelea, D.C.; Groza, F.; Gligor, O.; Vicaș, L.G.; Zdrîncă, M.; Lestyan, A.M.; Lestyan, M.; Venter, I.D.; Ganea, M.F.; et al. Emulgel with Origanum vulgare L. Oil: A New Therapeutic Proposal in Case of Dermal Bacterial Infections. Pharmaceuticals 2025, 18, 1768. https://doi.org/10.3390/ph18111768

AMA Style

Ganea M, Pelea DC, Groza F, Gligor O, Vicaș LG, Zdrîncă M, Lestyan AM, Lestyan M, Venter ID, Ganea MF, et al. Emulgel with Origanum vulgare L. Oil: A New Therapeutic Proposal in Case of Dermal Bacterial Infections. Pharmaceuticals. 2025; 18(11):1768. https://doi.org/10.3390/ph18111768

Chicago/Turabian Style

Ganea, Mariana, Diana Constanța Pelea, Florina (Miere) Groza, Octavia Gligor, Laura Grațiela Vicaș, Marcel Zdrîncă, Antonia Maria Lestyan, Marieta Lestyan, Ionuț Daniel Venter, Mădalin Florin Ganea, and et al. 2025. "Emulgel with Origanum vulgare L. Oil: A New Therapeutic Proposal in Case of Dermal Bacterial Infections" Pharmaceuticals 18, no. 11: 1768. https://doi.org/10.3390/ph18111768

APA Style

Ganea, M., Pelea, D. C., Groza, F., Gligor, O., Vicaș, L. G., Zdrîncă, M., Lestyan, A. M., Lestyan, M., Venter, I. D., Ganea, M. F., Maghiar, L., Ghitea, T. C., & Moisa, C. (2025). Emulgel with Origanum vulgare L. Oil: A New Therapeutic Proposal in Case of Dermal Bacterial Infections. Pharmaceuticals, 18(11), 1768. https://doi.org/10.3390/ph18111768

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