Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota for Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Case Report
Abstract
:1. Introduction
2. Case Presentation
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable (Unit; Normal Range) | Baseline | Post Phase 1 | Post Phase 2 | Post Phase 3 |
---|---|---|---|---|
Weight (kg) | 92.1 | 92.7 | 93.7 | 95.3 |
Height (cm) | 166 | 166 | 166 | 166 |
BMI (kg/m2) | 33.43 | 33.65 | 34.01 | 34.59 |
ASMI (kg/m2) | 7.40 | 7.37 | 7.22 | 7.46 |
PBMC Count (106/mL; 0.5–3) | 3.1 * | 2.8 | 5.4 * | 4.4 * |
Lymphocytes (%; 22–44) | 32.53 | 45.20 * | 38.48 | 37.27 |
Monocytes (%; 3–10) | 12.69 * | 9.23 | 9.78 | 8.64 |
Monocytes (absolute counts; 109/L; 0–0.8) | 0.84 * | 0.53 | 0.58 | 0.53 |
CRP (mg/L; 0–5) | 14.00 * | 3.60 | 3.80 | 4 |
SII | 420.28 | 206.68 | 323.96 | 334.19 |
PLR | 123.61 | 88.33 | 111.71 | 107.46 |
MLR | 0.39 | 0.21 | 0.26 | 0.23 |
NLR | 1.57 | 0.91 | 1.31 | 1.36 |
Bilirubin (total; μmol/L; 1.7–18.9) | 7.9 | 6.4 | 5.7 | 6.6 |
Alkaline phosphatase (U/L; 42–98) | 68 | 60 | 68 | 62 |
Variable/Measure (Unit) | Baseline | Post Phase 1 | Post Phase 2 | Post Phase 3 |
---|---|---|---|---|
PainDETECT Score | 27 | 24 | 26 | 18 |
FACT-GOG-Ntx Score | 37 | 34 | 44 | 48 |
FACT-GOG-Ntx TOI Score | 74 | 78 | 84 | 93 |
FACT-GOG Total Score | 67 | 77 | 73 | 81.3 |
GSLPA Score | 22 | 30 | 40 | 46 |
GS (m/s) | 0.91 | 1.00 | 1.08 | 1.16 |
5× STS (seconds) | 14.65 | 9.8 | 11.09 | 10.69 |
HGS (kg) | 27 | 28 | 29 | 30 |
9-HPT (seconds) | 19.3 | 17.8 | 18.34 | 16 |
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Vigano, M.; Kubal, S.; Lu, Y.; Habib, S.; Samarani, S.; Cama, G.; Viau, C.; Farzin, H.; Koudieh, N.; Xia, J.; et al. Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota for Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Case Report. Pharmaceuticals 2024, 17, 834. https://doi.org/10.3390/ph17070834
Vigano M, Kubal S, Lu Y, Habib S, Samarani S, Cama G, Viau C, Farzin H, Koudieh N, Xia J, et al. Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota for Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Case Report. Pharmaceuticals. 2024; 17(7):834. https://doi.org/10.3390/ph17070834
Chicago/Turabian StyleVigano, MariaLuisa, Sarah Kubal, Yao Lu, Sarah Habib, Suzanne Samarani, Georgina Cama, Charles Viau, Houman Farzin, Nebras Koudieh, Jianguo Xia, and et al. 2024. "Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota for Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Case Report" Pharmaceuticals 17, no. 7: 834. https://doi.org/10.3390/ph17070834
APA StyleVigano, M., Kubal, S., Lu, Y., Habib, S., Samarani, S., Cama, G., Viau, C., Farzin, H., Koudieh, N., Xia, J., Ahmad, A., Vigano, A., & Costiniuk, C. T. (2024). Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota for Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Case Report. Pharmaceuticals, 17(7), 834. https://doi.org/10.3390/ph17070834