Bipolar Radiofrequency and Non-Crosslinked Hyaluronic Acid Plus Calcium Hydroxyapatite in the Treatment of Stress Urinary Incontinence
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
- Group I—RF intravaginal application;
- Group II—NCLHA plus CaHA transvaginal periurethral injection;
- Group III—RF therapy combined with NCLHA plus CaHA injection.
4.1. Study Protocol
4.2. Radiofrequency
4.3. Non-Crosslinked Hyaluronic Acid and Calcium Hydroxyapatite (NCLAHA plus CaHA)
4.4. Post-Treatment Indications
4.5. Outocome Measures and Statistic Evaluation
4.6. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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HA | RF | HA + RF | p | Post-hoc | |
---|---|---|---|---|---|
ICIQ | 40.0 ± 7.30 | 49.4 ± 11.0 | 47.1 ± 11.4 | 0.010 | HA vs. RF, p = 0.009 HA vs. RF + HA, p = 0.063 RF vs. RF + HA, p = 0.601 |
UDI6 | 10.6 ± 3.5 | 12.5 ± 3.3 | 13.0 ± 3.9 | 0.073 | HA vs. RF, p = 0.145 HA vs. RF + HA, p = 0.145 RF vs. RF + HA, p = 0.823 |
Questionnaire | Group | Contrast | Estimate | p |
---|---|---|---|---|
ICIQ | HA | 8 weeks vs. baseline difference | −8.30 (−11.32, −5.28) | <0.001 |
RF | −18.0 (−21.11, −14.91) | <0.001 | ||
HA + RF | −13.9 (−16.77, −10.96) | <0.001 | ||
HA | 6 months vs. baseline difference | 3.85 (0.81, 6.90) | 0.0132 | |
RF | 6.8 (3.75–9.85) | <0.001 | ||
HA + RF | 2.0 (−0.90, 4.90) | 0.177 | ||
UDI6 | HA | 8 weeks vs. baseline difference | −4.8 (−6.20, −3.40) | <0.001 |
RF | −6.79 (−8.23, −5.35) | <0.001 | ||
HA + RF | −6.96 (−8.30, −5.61) | <0.001 | ||
HA | 6 months vs. baseline difference | 2.9 (1.49, 4.31) | <0.001 | |
RF | 2.35 (0.94, 3.76) | 0.001 | ||
HA + RF | 0.91 (−0.44, 2.26) | 0.186 |
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Kolczewski, P.; Łukaszuk, M.; Cymbaluk-Płoska, A.; Kozłowski, M.; Ciećwież, S.; Kuźlik, R.; Zerbinati, N. Bipolar Radiofrequency and Non-Crosslinked Hyaluronic Acid Plus Calcium Hydroxyapatite in the Treatment of Stress Urinary Incontinence. Pharmaceuticals 2024, 17, 622. https://doi.org/10.3390/ph17050622
Kolczewski P, Łukaszuk M, Cymbaluk-Płoska A, Kozłowski M, Ciećwież S, Kuźlik R, Zerbinati N. Bipolar Radiofrequency and Non-Crosslinked Hyaluronic Acid Plus Calcium Hydroxyapatite in the Treatment of Stress Urinary Incontinence. Pharmaceuticals. 2024; 17(5):622. https://doi.org/10.3390/ph17050622
Chicago/Turabian StyleKolczewski, Piotr, Mariusz Łukaszuk, Aneta Cymbaluk-Płoska, Mateusz Kozłowski, Sylwester Ciećwież, Rafał Kuźlik, and Nicola Zerbinati. 2024. "Bipolar Radiofrequency and Non-Crosslinked Hyaluronic Acid Plus Calcium Hydroxyapatite in the Treatment of Stress Urinary Incontinence" Pharmaceuticals 17, no. 5: 622. https://doi.org/10.3390/ph17050622
APA StyleKolczewski, P., Łukaszuk, M., Cymbaluk-Płoska, A., Kozłowski, M., Ciećwież, S., Kuźlik, R., & Zerbinati, N. (2024). Bipolar Radiofrequency and Non-Crosslinked Hyaluronic Acid Plus Calcium Hydroxyapatite in the Treatment of Stress Urinary Incontinence. Pharmaceuticals, 17(5), 622. https://doi.org/10.3390/ph17050622