Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor
Abstract
:1. Introduction
2. Results and Discussion
2.1. Influence of Synthesis Parameters on the Structural, Morphological and Magnetic Properties of Fe3O4 Nanoparticles
2.2. Magnetic Properties of the Prepared Magnetite Nanoparticles
2.3. Characterisation of Fe3O4 Nanoparticles Functionalised with Selenium-Based Drugs
2.4. Magnetic Hyperthermia Response
2.5. Toxicity of Fe3O4 Nanoparticles Functionalised with Selenium-Based Drugs
3. Materials and Methods
3.1. Materials
3.2. Methods
3.2.1. Preparation of Iron(III) Oleate
3.2.2. Synthesis of Fe3O4 Nanoparticles
3.2.3. Synthesis of Drug-Functionalised Copolymer and Coating Procedure
3.2.4. Physical, Structural and Magnetic Experimental Characterisation
3.2.5. Cytotoxicity Assay
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Sample | Iron(III) Oleate (mmol) | Oleic Acid (mmol) | ODE:DBE (mL) | Treflux (°C) | (311) Peak pos. (2θ) | DXRD (nm) | DTEM (nm) | % OM |
---|---|---|---|---|---|---|---|---|
Fe3O4_A | 5 | 10 | 10:10 | 304–295 | 35.661 | 11 ± 1 | 13 ± 1 | 12 |
Fe3O4_B | 5 | 10 | 12:06 | 312–297 | 35.637 | 18 ± 1 | 18 ± 2 | 10 |
Sample | DTEM (nm) | Ms RT (Am2kg−1) | Ms 5 K (Am2kg−1) | Mr/Ms 5 K | Hc 300 K (mT) | Hc 5 K (mT) | ΔHpp (Gauss) | |
---|---|---|---|---|---|---|---|---|
Fe3O4_A | 13 ± 1 | 78 | 113 | 0.31 | 0.26 | 18 | 3.66 | 304 |
Fe3O4_B | 18 ± 2 | 92 | 108 | 0.43 | 0.75 | 40 | 3.32 | 458 |
Sample | Fe Content ng/mL | Se Content ng/mL | Number of Drug Molecules/NP | Dwater (nm) | DPBS (nm) | ζ (mV) |
---|---|---|---|---|---|---|
Fe3O4_A@PD | 3987 | <0.1 | - | 52 ± 19 | 36 ± 6 | −49 |
Fe3O4_A@PD–PEG12.5% | 3505 | <0.1 | - | 54 ± 6 | 58 ± 1 | −41 |
Fe3O4_A@PD–EM102 | 4971 | 33 | 349 | 34 ± 14 | 32 ± 7 | −50 |
Fe3O4_A@PD–EM102–PEG | 4613 | 10.8 | 123 | 55 ± 8 | 49 ± 12 | −45 |
Fe3O4_B@PD | 3676 | <0.1 | - | 100 ± 29 | 71 ± 30 | −50 |
Fe3O4_B@PD–PEG25% | 3835 | <0.1 | - | 62 ± 17 | 46 ± 19 | −43 |
Fe3O4_B@PD–EM102 | 4162 | 6.8 | 63 | 48 ± 8 | 45 ± 2 | −51 |
Fe3O4_B@PD–EM102–PEG | 5084 | 20.5 | 154 | 73 ± 15 | 45 ± 18 | −47 |
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Galarreta-Rodriguez, I.; Etxebeste-Mitxeltorena, M.; Moreno, E.; Plano, D.; Sanmartín, C.; Megahed, S.; Feliu, N.; Parak, W.J.; Garaio, E.; Gil de Muro, I.; et al. Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor. Pharmaceuticals 2023, 16, 949. https://doi.org/10.3390/ph16070949
Galarreta-Rodriguez I, Etxebeste-Mitxeltorena M, Moreno E, Plano D, Sanmartín C, Megahed S, Feliu N, Parak WJ, Garaio E, Gil de Muro I, et al. Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor. Pharmaceuticals. 2023; 16(7):949. https://doi.org/10.3390/ph16070949
Chicago/Turabian StyleGalarreta-Rodriguez, Itziar, Mikel Etxebeste-Mitxeltorena, Esther Moreno, Daniel Plano, Carmen Sanmartín, Saad Megahed, Neus Feliu, Wolfgang J. Parak, Eneko Garaio, Izaskun Gil de Muro, and et al. 2023. "Preparation of Selenium-Based Drug-Modified Polymeric Ligand-Functionalised Fe3O4 Nanoparticles as Multimodal Drug Carrier and Magnetic Hyperthermia Inductor" Pharmaceuticals 16, no. 7: 949. https://doi.org/10.3390/ph16070949