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Review

Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2

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Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, 69100 Villeurbanne, France
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Birla Institute of Technology and Science-Pilani, Hyderabad 500078, India
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Department of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine
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CONEM Ukraine Life Science Research Group, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine
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I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine
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Department of Chemical, Physics, Mathematics and Natural Sciences, University of Sassari, 07100 Sassari, Italy
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Académie Internationale de Médecine Dentaire Intégrative, 75000 Paris, France
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Bogomolets National Medical University, 01601 Kyiv, Ukraine
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Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610 Mo i Rana, Norway
*
Author to whom correspondence should be addressed.
Academic Editors: Fernando Calzada and Miguel Valdes
Pharmaceuticals 2022, 15(9), 1049; https://doi.org/10.3390/ph15091049
Received: 29 July 2022 / Revised: 17 August 2022 / Accepted: 20 August 2022 / Published: 25 August 2022
(This article belongs to the Special Issue Pharmacological Activities of Flavonoids and Its Analogues)
The COVID-19 outbreak seems to be the most dangerous challenge of the third millennium due to its highly contagious nature. Amongst natural molecules for COVID-19 treatment, the flavonoid molecule quercetin (QR) is currently considered one of the most promising. QR is an active agent against SARS and MERS due to its antimicrobial, antiviral, anti-inflammatory, antioxidant, and some other beneficial effects. QR may hold therapeutic potential against SARS-CoV-2 due to its inhibitory effects on several stages of the viral life cycle. In fact, QR inhibits viral entry, absorption, and penetration in the SARS-CoV virus, which might be at least partly explained by the ability of QR and its derivatives to inhibit 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro). QR is a potent immunomodulatory molecule due to its direct modulatory effects on several immune cells, cytokines, and other immune molecules. QR-based nanopreparations possess enhanced bioavailability and solubility in water. In this review, we discuss the prospects for the application of QR as a preventive and treatment agent for COVID-19. Given the multifactorial beneficial action of QR, it can be considered a very valid drug as a preventative, mitigating, and therapeutic agent of COVID-19 infection, especially in synergism with zinc, vitamins C, D, and E, and other polyphenols. View Full-Text
Keywords: quercetin; coronavirus; COVID-19; infection; SARS-CoV-2; nanopreparations; prevention; treatment quercetin; coronavirus; COVID-19; infection; SARS-CoV-2; nanopreparations; prevention; treatment
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MDPI and ACS Style

Gasmi, A.; Mujawdiya, P.K.; Lysiuk, R.; Shanaida, M.; Peana, M.; Gasmi Benahmed, A.; Beley, N.; Kovalska, N.; Bjørklund, G. Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2. Pharmaceuticals 2022, 15, 1049. https://doi.org/10.3390/ph15091049

AMA Style

Gasmi A, Mujawdiya PK, Lysiuk R, Shanaida M, Peana M, Gasmi Benahmed A, Beley N, Kovalska N, Bjørklund G. Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2. Pharmaceuticals. 2022; 15(9):1049. https://doi.org/10.3390/ph15091049

Chicago/Turabian Style

Gasmi, Amin, Pavan Kumar Mujawdiya, Roman Lysiuk, Mariia Shanaida, Massimiliano Peana, Asma Gasmi Benahmed, Nataliya Beley, Nadiia Kovalska, and Geir Bjørklund. 2022. "Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2" Pharmaceuticals 15, no. 9: 1049. https://doi.org/10.3390/ph15091049

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