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Article
Peer-Review Record

Efficacy of Adaptogens in Patients with Long COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial

Pharmaceuticals 2022, 15(3), 345; https://doi.org/10.3390/ph15030345
by Irina Karosanidze 1, Ushangi Kiladze 1, Nino Kirtadze 1, Mikhail Giorgadze 1, Nana Amashukeli 1, Nino Parulava 1, Neli Iluridze 1, Nana Kikabidze 1, Nana Gudavadze 1, Lali Gelashvili 1, Vazha Koberidze 1, Eka Gigashvili 1, Natela Jajanidze 1, Naira Latsabidze 1, Nato Mamageishvili 2, Ramaz Shengelia 2, Areg Hovhannisyan 3 and Alexander Panossian 4,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Pharmaceuticals 2022, 15(3), 345; https://doi.org/10.3390/ph15030345
Submission received: 15 February 2022 / Revised: 1 March 2022 / Accepted: 9 March 2022 / Published: 11 March 2022
(This article belongs to the Special Issue COVID-19 in Pharmaceuticals)

Round 1

Reviewer 1 Report

Dear Authors I have read the manuscript and I think that it is very interesting, however I think that more data related to cytokines must be added in both results and discussion.

In fact the role of IL-6 has been well documented and some authors reported that other proinflammatory mediators are involved in neuroinflammation. Therefore I think that you must add these data in results as well as in discussion (see  doi: 10.1371/journal.pone.0251819).

Moreover, please add the CT of COVID for each group in order to evaluate if the viral activity could play a role in clinical response 

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Minor revision

The descriptive analysis in the Result is not particularly compelling. As a matter of fact, it is necessary to emphasize the Result.

In my opinion and observation, the outcome portion of this study requires a much more conventional description. As we all know, a lot of studies on COVID-related research have already been published. As a consequence, it is necessary to emphasise the outcomes and compare them to the previous report.

 

Author Response

Please see the attachment

Author Response File: Author Response.pdf

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