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Review

Extracellular Vesicles in Skin Wound Healing

1
Laboratory of Pharmaceutical Sciences, Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania
2
Preclinical Research Laboratory for Medicinal Products, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Contributed equally.
Academic Editors: Samir EL Andaloussi, Joel Nordin, Daniel W. Hagey and André Görgens
Pharmaceuticals 2021, 14(8), 811; https://doi.org/10.3390/ph14080811
Received: 30 July 2021 / Revised: 13 August 2021 / Accepted: 16 August 2021 / Published: 18 August 2021
Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-based signaling takes part in all four wound healing phases: hemostasis, inflammation, proliferation, and remodeling. Such an extensive involvement of EVs suggests exploiting their action to modulate the impaired healing phase. Furthermore, next to their natural wound healing capacity, EVs can be engineered for better defined pharmaceutical purposes, such as carrying specific cargo or targeting specific destinations by labelling them with certain surface proteins. This review aims to promote scientific awareness in basic and translational research of EVs by summarizing the current knowledge about their natural role in each stage of skin repair and the most recent findings in application areas, such as wound healing, skin regeneration, and treatment of dermal diseases, including the stem cell-derived, plant-derived, and engineered EVs. View Full-Text
Keywords: extracellular vesicles; EVs; exosomes; mesenchymal stem cell EVs; plant-derived EVs; wound healing; scaffolds extracellular vesicles; EVs; exosomes; mesenchymal stem cell EVs; plant-derived EVs; wound healing; scaffolds
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MDPI and ACS Style

Narauskaitė, D.; Vydmantaitė, G.; Rusteikaitė, J.; Sampath, R.; Rudaitytė, A.; Stašytė, G.; Aparicio Calvente, M.I.; Jekabsone, A. Extracellular Vesicles in Skin Wound Healing. Pharmaceuticals 2021, 14, 811. https://doi.org/10.3390/ph14080811

AMA Style

Narauskaitė D, Vydmantaitė G, Rusteikaitė J, Sampath R, Rudaitytė A, Stašytė G, Aparicio Calvente MI, Jekabsone A. Extracellular Vesicles in Skin Wound Healing. Pharmaceuticals. 2021; 14(8):811. https://doi.org/10.3390/ph14080811

Chicago/Turabian Style

Narauskaitė, Deimantė, Gabrielė Vydmantaitė, Justina Rusteikaitė, Revathi Sampath, Akvilė Rudaitytė, Gabija Stašytė, María I. Aparicio Calvente, and Aistė Jekabsone. 2021. "Extracellular Vesicles in Skin Wound Healing" Pharmaceuticals 14, no. 8: 811. https://doi.org/10.3390/ph14080811

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