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Article

Morin-5′-Sulfonic Acid Sodium Salt (NaMSA) Attenuates Cyclophosphamide-Induced Histological Changes in Genitourinary Tract in Rats—Short Report

by
Anna Merwid-Ląd
1,*,
Dorota Ksiądzyna
1,
Agnieszka Hałoń
2,
Danuta Szkudlarek
3,
Małgorzata Trocha
1,
Marta Szandruk-Bender
1,
Agnieszka Matuszewska
1,
Beata Nowak
1,
Tomasz Sozański
1,
Anna Kuźniar
4 and
Adam Szeląg
1
1
Department of Pharmacology, Wroclaw Medical University, ul. Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland
2
Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wrocław, Poland
3
Department of Pathomorphology, Wroclaw Medical University, ul. Marcinkowkiego 1, 50-368 Wrocław, Poland
4
Department of Inorganic and Analytical Chemistry, Rzeszow University of Technology, al. Powstańców Warszawy 6, 35-959 Rzeszów, Poland
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2021, 14(3), 192; https://doi.org/10.3390/ph14030192
Submission received: 1 February 2021 / Revised: 18 February 2021 / Accepted: 23 February 2021 / Published: 26 February 2021
(This article belongs to the Special Issue Anticancer Drugs 2021)
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Abstract

Cyclophosphamide (CPX) exerts toxicity in the urogenital system. The current study was designed to evaluate the effect of morin-5′-sulfonic acid sodium salt (NaMSA) on CPX-induced urogenital toxicity in rats. NaMSA (100 mg/kg/daily) and CPX (15 mg/kg/daily) alone or in combination and 0.9% NaCl (as a control) were given intragastrically for 10 days. Testes and epididymes from male and urinary bladders from male and female rats were evaluated histologically. In testes and epididymes, morphological changes and relative decrease in sperm count were assessed. In urinary bladders edema, hemorrhage and urothelium erosions were described by 0–2 points scoring system. Reproductive score (RS—in total 6 points) and urinary bladder score (BS—in total 6 points) were thereafter calculated. In CPX-receiving group RS (2.7) and BS (3.3) were significantly higher than in the control (0.5 and 0.25 for RS and BS, respectively). Co-administration of NaMSA reversed most of the morphological changes, which was reflected by lower RS and BS score (0.5 and 1.2 for RS and BS, respectively). The preliminary findings suggest that NaMSA may attenuate CPX-induced histological changes in rat urogenital tract.
Keywords: NaMSA; cyclophosphamide; histopathology; testis; urinary bladder NaMSA; cyclophosphamide; histopathology; testis; urinary bladder

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MDPI and ACS Style

Merwid-Ląd, A.; Ksiądzyna, D.; Hałoń, A.; Szkudlarek, D.; Trocha, M.; Szandruk-Bender, M.; Matuszewska, A.; Nowak, B.; Sozański, T.; Kuźniar, A.; et al. Morin-5′-Sulfonic Acid Sodium Salt (NaMSA) Attenuates Cyclophosphamide-Induced Histological Changes in Genitourinary Tract in Rats—Short Report. Pharmaceuticals 2021, 14, 192. https://doi.org/10.3390/ph14030192

AMA Style

Merwid-Ląd A, Ksiądzyna D, Hałoń A, Szkudlarek D, Trocha M, Szandruk-Bender M, Matuszewska A, Nowak B, Sozański T, Kuźniar A, et al. Morin-5′-Sulfonic Acid Sodium Salt (NaMSA) Attenuates Cyclophosphamide-Induced Histological Changes in Genitourinary Tract in Rats—Short Report. Pharmaceuticals. 2021; 14(3):192. https://doi.org/10.3390/ph14030192

Chicago/Turabian Style

Merwid-Ląd, Anna, Dorota Ksiądzyna, Agnieszka Hałoń, Danuta Szkudlarek, Małgorzata Trocha, Marta Szandruk-Bender, Agnieszka Matuszewska, Beata Nowak, Tomasz Sozański, Anna Kuźniar, and et al. 2021. "Morin-5′-Sulfonic Acid Sodium Salt (NaMSA) Attenuates Cyclophosphamide-Induced Histological Changes in Genitourinary Tract in Rats—Short Report" Pharmaceuticals 14, no. 3: 192. https://doi.org/10.3390/ph14030192

APA Style

Merwid-Ląd, A., Ksiądzyna, D., Hałoń, A., Szkudlarek, D., Trocha, M., Szandruk-Bender, M., Matuszewska, A., Nowak, B., Sozański, T., Kuźniar, A., & Szeląg, A. (2021). Morin-5′-Sulfonic Acid Sodium Salt (NaMSA) Attenuates Cyclophosphamide-Induced Histological Changes in Genitourinary Tract in Rats—Short Report. Pharmaceuticals, 14(3), 192. https://doi.org/10.3390/ph14030192

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