Next Article in Journal
Acute Pharmacological Effects of Oral and Intranasal Mephedrone: An Observational Study in Humans
Next Article in Special Issue
Cytostatic Action of Novel Histone Deacetylase Inhibitors in Androgen Receptor-Null Prostate Cancer Cells
Previous Article in Journal
Immobilization of Chondroitin Sulfate A onto Monolithic Epoxy Silica Column as a New Chiral Stationary Phase for High-Performance Liquid Chromatographic Enantioseparation
Previous Article in Special Issue
Influence of Estrogenic Metabolic Pathway Genes Polymorphisms on Postmenopausal Breast Cancer Risk
Open AccessReview

Reuse of Molecules for Glioblastoma Therapy

1
Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
2
Division of Pharmaceutical Sciences, University of Cincinnati James L. Winkle College of Pharmacy, Cincinnati, OH 45229, USA
3
Department of Dermatology, Emory School of Medicine, Atlanta, GA 30322, USA
4
Atlanta Veterans Administration Medical Center, Decatur, GA 30033, USA
5
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
6
Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
7
Department of Pharmacology and Chemical Biology, Emory School of Medicine, Atlanta, GA 30322, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Mike-Andrew Westhoff and Georg Karpel-Massler
Pharmaceuticals 2021, 14(2), 99; https://doi.org/10.3390/ph14020099
Received: 14 January 2021 / Accepted: 25 January 2021 / Published: 28 January 2021
(This article belongs to the Special Issue Malignant Glioma: Novel Therapeutic Strategies)
Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor. The current standard of care for GBM is the Stupp protocol which includes surgical resection, followed by radiotherapy concomitant with the DNA alkylator temozolomide; however, survival under this treatment regimen is an abysmal 12–18 months. New and emerging treatments include the application of a physical device, non-invasive ‘tumor treating fields’ (TTFs), including its concomitant use with standard of care; and varied vaccines and immunotherapeutics being trialed. Some of these approaches have extended life by a few months over standard of care, but in some cases are only available for a minority of GBM patients. Extensive activity is also underway to repurpose and reposition therapeutics for GBM, either alone or in combination with the standard of care. In this review, we present select molecules that target different pathways and are at various stages of clinical translation as case studies to illustrate the rationale for their repurposing-repositioning and potential clinical use. View Full-Text
Keywords: glioblastoma; brain cancer; letrozole; S6K1 inhibitors; imipramine blue; Visudyne®; CellCept®; saposin C glioblastoma; brain cancer; letrozole; S6K1 inhibitors; imipramine blue; Visudyne®; CellCept®; saposin C
Show Figures

Figure 1

MDPI and ACS Style

Koehler, A.; Karve, A.; Desai, P.; Arbiser, J.; Plas, D.R.; Qi, X.; Read, R.D.; Sasaki, A.T.; Gawali, V.S.; Toukam, D.K.; Bhattacharya, D.; Kallay, L.; Pomeranz Krummel, D.A.; Sengupta, S. Reuse of Molecules for Glioblastoma Therapy. Pharmaceuticals 2021, 14, 99. https://doi.org/10.3390/ph14020099

AMA Style

Koehler A, Karve A, Desai P, Arbiser J, Plas DR, Qi X, Read RD, Sasaki AT, Gawali VS, Toukam DK, Bhattacharya D, Kallay L, Pomeranz Krummel DA, Sengupta S. Reuse of Molecules for Glioblastoma Therapy. Pharmaceuticals. 2021; 14(2):99. https://doi.org/10.3390/ph14020099

Chicago/Turabian Style

Koehler, Abigail; Karve, Aniruddha; Desai, Pankaj; Arbiser, Jack; Plas, David R.; Qi, Xiaoyang; Read, Renee D.; Sasaki, Atsuo T.; Gawali, Vaibhavkumar S.; Toukam, Donatien K.; Bhattacharya, Debanjan; Kallay, Laura; Pomeranz Krummel, Daniel A.; Sengupta, Soma. 2021. "Reuse of Molecules for Glioblastoma Therapy" Pharmaceuticals 14, no. 2: 99. https://doi.org/10.3390/ph14020099

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop