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The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure

Biochemistry and Molecular Biology Department, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
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Academic Editor: Mary Meegan
Pharmaceuticals 2021, 14(2), 96; https://doi.org/10.3390/ph14020096
Received: 28 December 2020 / Revised: 20 January 2021 / Accepted: 22 January 2021 / Published: 27 January 2021
(This article belongs to the Special Issue Quadruplex Nucleic Acid Ligands in Drug Discovery)
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-motif. When within promoter regions, the i-motif has the potential to act as a molecular switch for controlling gene expression. However, i-motif structures in genomic areas of repetitive nucleotide sequences may play a role in facilitating or hindering expansion of these DNA elements. Despite research on the i-motif trailing behind the complementary G-quadruplex structure, recent discoveries including the identification of a specific i-motif antibody are pushing this field forward. This perspective reviews initial and current work characterizing the i-motif and providing insight into the biological function of this DNA structure, with a focus on how the i-motif can serve as a molecular target for developing new therapeutic approaches to modulate gene expression and extension of repetitive DNA. View Full-Text
Keywords: i-motif; DNA quadruplex structures; transcription regulation; cancer therapeutics i-motif; DNA quadruplex structures; transcription regulation; cancer therapeutics
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MDPI and ACS Style

Brown, S.L.; Kendrick, S. The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure. Pharmaceuticals 2021, 14, 96. https://doi.org/10.3390/ph14020096

AMA Style

Brown SL, Kendrick S. The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure. Pharmaceuticals. 2021; 14(2):96. https://doi.org/10.3390/ph14020096

Chicago/Turabian Style

Brown, Susie L., and Samantha Kendrick. 2021. "The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure" Pharmaceuticals 14, no. 2: 96. https://doi.org/10.3390/ph14020096

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