Next Article in Journal
Limited Sampling Strategy for Determination of Ibrutinib Plasma Exposure: Joint Analyses with Metabolite Data
Next Article in Special Issue
Modification of Bacteriophages to Increase Their Association with Lung Epithelium Cells In Vitro
Previous Article in Journal
Design and Mechanism of Action of a New Prototype of Combi-Molecule “Programed” to Release Bioactive Species at a pH Range Akin to That of the Tumor Microenvironment
Review

Bacteriophages as Therapeutic and Diagnostic Vehicles in Cancer

1
Department of Oncology, University of Torino, 10060 Candiolo, Italy
2
Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Paul Hyman
Pharmaceuticals 2021, 14(2), 161; https://doi.org/10.3390/ph14020161
Received: 29 January 2021 / Revised: 15 February 2021 / Accepted: 16 February 2021 / Published: 17 February 2021
(This article belongs to the Special Issue Bacteriophages as Therapeutic Delivery Vehicles)
Evolution of nanomedicine is the re-design of synthetic and biological carriers to implement novel theranostic platforms. In recent years, bacteriophage research favors this process, which has opened up new roads in drug and gene delivery studies. By displaying antibodies, peptides, or proteins on the surface of different bacteriophages through the phage display technique, it is now possible to unravel specific molecular determinants of both cancer cells and tumor-associated microenvironmental molecules. Downstream applications are manifold, with peptides being employed most of the times to functionalize drug carriers and improve their therapeutic index. Bacteriophages themselves were proven, in this scenario, to be good carriers for imaging molecules and therapeutics as well. Moreover, manipulation of their genetic material to stably vehiculate suicide genes within cancer cells substantially changed perspectives in gene therapy. In this review, we provide examples of how amenable phages can be used as anticancer agents, especially because their systemic administration is possible. We also provide some insights into how their immunogenic profile can be modulated and exploited in immuno-oncology for vaccine production. View Full-Text
Keywords: biopanning; drug delivery; gene therapy; phage display; targeting biopanning; drug delivery; gene therapy; phage display; targeting
Show Figures

Figure 1

MDPI and ACS Style

Foglizzo, V.; Marchiò, S. Bacteriophages as Therapeutic and Diagnostic Vehicles in Cancer. Pharmaceuticals 2021, 14, 161. https://doi.org/10.3390/ph14020161

AMA Style

Foglizzo V, Marchiò S. Bacteriophages as Therapeutic and Diagnostic Vehicles in Cancer. Pharmaceuticals. 2021; 14(2):161. https://doi.org/10.3390/ph14020161

Chicago/Turabian Style

Foglizzo, Valentina, and Serena Marchiò. 2021. "Bacteriophages as Therapeutic and Diagnostic Vehicles in Cancer" Pharmaceuticals 14, no. 2: 161. https://doi.org/10.3390/ph14020161

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop