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Article

NanoUPLC-QTOF-MS/MS Determination of Major Rosuvastatin Degradation Products Generated by Gamma Radiation in Aqueous Solution

1
Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia
2
Department of Biochemical Bioengineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia
3
Division of Materials Chemistry, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia
4
Faculty of Chemistry, Adam Mickiewicz University in Poznan, Uniwersytetu Poznanskiego 8, 61-614 Poznan, Poland
5
Research and Development Ltd., PLIVA, Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Academic Editors: Abdelwahab Omri, Luisa Barreiros and Marcela Segundo
Pharmaceuticals 2021, 14(11), 1160; https://doi.org/10.3390/ph14111160
Received: 27 August 2021 / Revised: 4 November 2021 / Accepted: 10 November 2021 / Published: 13 November 2021
(This article belongs to the Special Issue Analytical Techniques in the Pharmaceutical Sciences)
Rosuvastatin, a member of the statin family of drugs, is used to regulate high cholesterol levels in the human body. Moreover, rosuvastatin and other statins demonstrate a protective role against free radical-induced oxidative stress. Our research aimed to investigate the end-products of free radical-induced degradation of rosuvastatin. To induce the radical degradation, an aqueous solution of rosuvastatin was irradiated using different doses of gamma radiation (50–1000 Gy) under oxidative conditions. Rosuvastatin and related degradation products were separated on nanoC18 column under gradient elution, and identification was carried out on hyphenated nanoUPLC and nanoESI-QTOF mass spectrometer system. Elemental composition analysis using highly accurate mass measurements together with isotope fitting algorithm identified nine major degradation products. This is the first study of gamma radiation-induced degradation of rosuvastatin, where chemical structures, MS/MS fragmentation pathways and formation mechanisms of the resulting degradation products are detailly described. The presented results contribute to the understanding of the degradation pathway of rosuvastatin and possibly other statins under gamma radiation conditions. View Full-Text
Keywords: rosuvastatin; nanoLC-MS; gamma radiation; degradation products identification; OH radical mechanisms rosuvastatin; nanoLC-MS; gamma radiation; degradation products identification; OH radical mechanisms
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MDPI and ACS Style

Dončević, L.; Svetličić, E.; Hozić, A.; Mihaljević, B.; Jarmużek, D.; Tartaro Bujak, I.; Pluskota-Karwatka, D.; Ozdanovac, L.; Džeba, I.; Cindrić, M. NanoUPLC-QTOF-MS/MS Determination of Major Rosuvastatin Degradation Products Generated by Gamma Radiation in Aqueous Solution. Pharmaceuticals 2021, 14, 1160. https://doi.org/10.3390/ph14111160

AMA Style

Dončević L, Svetličić E, Hozić A, Mihaljević B, Jarmużek D, Tartaro Bujak I, Pluskota-Karwatka D, Ozdanovac L, Džeba I, Cindrić M. NanoUPLC-QTOF-MS/MS Determination of Major Rosuvastatin Degradation Products Generated by Gamma Radiation in Aqueous Solution. Pharmaceuticals. 2021; 14(11):1160. https://doi.org/10.3390/ph14111160

Chicago/Turabian Style

Dončević, Lucija, Ema Svetličić, Amela Hozić, Branka Mihaljević, Dorota Jarmużek, Ivana Tartaro Bujak, Donata Pluskota-Karwatka, Luka Ozdanovac, Iva Džeba, and Mario Cindrić. 2021. "NanoUPLC-QTOF-MS/MS Determination of Major Rosuvastatin Degradation Products Generated by Gamma Radiation in Aqueous Solution" Pharmaceuticals 14, no. 11: 1160. https://doi.org/10.3390/ph14111160

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