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Open AccessArticle

Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells

Department of Chemistry, Babes-Bolyai University, 400028 Cluj-Napoca, Romania
Tumor Biology Laboratory, Institute of Oncology I. Chiricuta, 400015 Cluj-Napoca, Romania
Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400037 Cluj-Napoca, Romania
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(6), 107;
Received: 20 April 2020 / Revised: 22 May 2020 / Accepted: 22 May 2020 / Published: 27 May 2020
(This article belongs to the Special Issue COVID-19 in Pharmaceuticals)
Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent. View Full-Text
Keywords: hemoglobin; albumin; ascorbate; erythrocyte; antioxidant; leukocyte; COVID-19 hemoglobin; albumin; ascorbate; erythrocyte; antioxidant; leukocyte; COVID-19
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Lehene, M.; Fischer-Fodor, E.; Scurtu, F.; Hădade, N.D.; Gal, E.; Mot, A.C.; Matei, A.; Silaghi-Dumitrescu, R. Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells. Pharmaceuticals 2020, 13, 107.

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