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Open AccessArticle

Mantonico and Pecorello Grape Seed Extracts: Chemical Characterization and Evaluation of In Vitro Wound-Healing and Anti-Inflammatory Activities

1
Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence 2018-2022, University of Calabria, Edificio Polifunzionale, 87036 Rende (CS), Italy
2
Department of Chemistry, University of Rome “La Sapienza”, Piazzale Aldo Moro 5, 00185 Rome, Italy
3
Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
4
Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Seville, C/O Prof. García González, 41071 Seville, Spain
5
Department of Drug Science and Technology, University of Turin, Via P. Guria 9, 10125 Turin, Italy
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(5), 97; https://doi.org/10.3390/ph13050097
Received: 23 April 2020 / Revised: 6 May 2020 / Accepted: 12 May 2020 / Published: 14 May 2020
(This article belongs to the Special Issue Medicinal Plants 2020)
The winemaking process produces a huge number of pomaces that generally are used for energy purposes. Further valuable applications such as health-promoting properties are still under investigation. The seeds of the white berries of Mantonico and Pecorello cv. were extracted in a Soxhlet apparatus, using n-hexane and chloroform as solvents. Extracts were characterized by NMR and GC-MS analyses. They were assayed in vitro as wound healing and anti-inflammatory agents in HaCaT and RAW 264.7 cell lines, respectively. n-hexane Mantonico extract resulted in the most interesting wound healing sample, while n-hexane Pecorello, containing a good number of carotenoids, resulted in a good anti-inflammatory candidate. These preliminary findings underlined the benefit of grape seed extracts valorization due to their health-promoting properties. View Full-Text
Keywords: Soxhlet; grape seeds; anti-inflammatory; wound healing; lipophilic fraction; carotenoids; HaCaT cell line; RAW 264.7 cell line; NMR; GC-MS Soxhlet; grape seeds; anti-inflammatory; wound healing; lipophilic fraction; carotenoids; HaCaT cell line; RAW 264.7 cell line; NMR; GC-MS
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MDPI and ACS Style

Carullo, G.; Sciubba, F.; Governa, P.; Mazzotta, S.; Frattaruolo, L.; Grillo, G.; Cappello, A.R.; Cravotto, G.; Di Cocco, M.E.; Aiello, F. Mantonico and Pecorello Grape Seed Extracts: Chemical Characterization and Evaluation of In Vitro Wound-Healing and Anti-Inflammatory Activities. Pharmaceuticals 2020, 13, 97.

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