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Open AccessTechnical Note

A Fast and Simple Method for the Determination of TBA in 18F-Labeled Radiopharmaceuticals

Center for Nuclear medicine/PET, Department of Radiology, Haukeland University Hospital, Jonas Lies vei 65, N-5021 Bergen, Norway
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Pharmaceuticals 2020, 13(2), 27; https://doi.org/10.3390/ph13020027
Received: 15 January 2020 / Revised: 5 February 2020 / Accepted: 10 February 2020 / Published: 11 February 2020
(This article belongs to the Section Radiopharmaceutical Sciences)
A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various 18F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the 18F-radiopharmaceutical to be tested and TBA, then with deionized water or hydrogen peroxide (H2O2) solution, depending on if an antioxidant stabilizer is part of the pharmaceutical matrix. A distinct brown spot is visible at TBA concentrations of 50 µg/mL and up.
Keywords: tetrabutylammonium; TBA; PET; quality control; spot test; radiopharmaceuticals; PSMA; FDOPA; FDG; iodoplatinate tetrabutylammonium; TBA; PET; quality control; spot test; radiopharmaceuticals; PSMA; FDOPA; FDG; iodoplatinate
MDPI and ACS Style

Halvorsen, N.E.; Kvernenes, O.H. A Fast and Simple Method for the Determination of TBA in 18F-Labeled Radiopharmaceuticals. Pharmaceuticals 2020, 13, 27.

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