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Open AccessReview

Ultrasound for Drug Synthesis: A Green Approach

Univ. Savoie Mont Blanc - LCME, F-73000 Chambéry, France
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Pharmaceuticals 2020, 13(2), 23; https://doi.org/10.3390/ph13020023
Received: 22 December 2019 / Revised: 22 January 2020 / Accepted: 22 January 2020 / Published: 31 January 2020
(This article belongs to the Special Issue New Tools for Medicinal Chemists)
This last century, the development of new medicinal molecules represents a real breakthrough in terms of humans and animal life expectancy and quality of life. However, this success is tainted by negative environmental consequences. Indeed, the synthesis of drug candidates requires the use of many chemicals, solvents, and processes that are very hazardous, toxic, energy consuming, expensive, and generates a large amount of waste. Many large pharmaceutical companies have thus moved to using green chemistry practices for drug discovery, development, and manufacturing. One of them is the use of energy-efficient activation techniques, such as ultrasound. This review summarizes the latest most representative works published on the use of ultrasound for sustainable bioactive molecules synthesis.
Keywords: ultrasound; sustainable drugs synthesis; sonochemistry; green oxidations; green reductions; enzymatic transformations ultrasound; sustainable drugs synthesis; sonochemistry; green oxidations; green reductions; enzymatic transformations
MDPI and ACS Style

Draye, M.; Chatel, G.; Duwald, R. Ultrasound for Drug Synthesis: A Green Approach. Pharmaceuticals 2020, 13, 23.

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