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Voltammetric Evaluation of Diclofenac Tablets Samples through Carbon Black-Based Electrodes

Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO 74690-970, Brazil
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Pharmaceuticals 2019, 12(2), 83; https://doi.org/10.3390/ph12020083
Received: 5 April 2019 / Revised: 2 May 2019 / Accepted: 8 May 2019 / Published: 4 June 2019
(This article belongs to the Special Issue Advanced Electrochemical Sensors in Drug Sensing)
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Abstract

Diclofenac (DIC) is a non-steroidal anti-inflammatory drug of wide use around the world. Electroanalytical methods display a high analytical potential for application in pharmaceutical samples but the drawbacks concerning electrode fouling and reproducibility are of major concern. Henceforth, the aim of this work was to propose the use of alternative low-cost carbon black (CB) and ionic liquid (IL) matrix to modify the surface of pencil graphite electrodes (PGE) in order to quantify DIC in raw materials, intermediates, and final products, as well as in stability assays of tablets. The proposed method using CB+IL/PGE displayed good recovery (99.4%) as well as limits of detection (LOD) of 0.08 µmol L-1 and limits of quantification (LOQ) of 0.28 µmol L−1. CB+IL/PGE response was five times greater than the unmodified PGE. CB+IL-PGE stands as an interesting alternative for DIC assessment in different pharmaceutical samples. View Full-Text
Keywords: pharmaceutical electroanalysis; stability assays; anti-inflammatory drugs; pencil graphite electrodes pharmaceutical electroanalysis; stability assays; anti-inflammatory drugs; pencil graphite electrodes
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da Cunha, C.E.P.; Rodrigues, E.S.B.; Fernandes Alecrim, M.; Thomaz, D.V.; Macêdo, I.Y.L.; Garcia, L.F.; de Oliveira Neto, J.R.; Moreno, E.K.G.; Ballaminut, N.; de Souza Gil, E. Voltammetric Evaluation of Diclofenac Tablets Samples through Carbon Black-Based Electrodes. Pharmaceuticals 2019, 12, 83.

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