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Thiopental and Phenytoin as Novel Ionophores for Potentiometric Determination of Lead (II) Ions

Environmental Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), Minufiya University, Sadat City, Egypt
2 Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt
Chemistry Department, Faculty of Sciences, Minufiya University, Egypt
Author to whom correspondence should be addressed.
Sensors 2009, 9(3), 1860-1875;
Received: 20 January 2009 / Revised: 23 February 2009 / Accepted: 9 March 2009 / Published: 13 March 2009
(This article belongs to the Section Chemical Sensors)
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Two novel polymeric membrane sensors for the analysis of Pb(II) have been developed based ontwo therapeutic drugs, thiopental (TP) and phenytoin (PT) as two new ionophores and potassium tetrakis(p-chlorophenyl) borate (KTpClPB) as a lipophilic additive, in plasticized PVC membranes. The sensors show a Nernstian response for Pb(II) ions over the wide concentration ranges of 1×10-2 - 7×10-6 M and 1×10-2 - 8×10-6 M for the sensors based on thiopental and phenytoin, respectively. The proposed sensors have a fast response time and can be used for more than nine weeks without any considerable divergence in potentials. The sensors exhibit comparatively good selectivity with respect to alkaline, alkaline earth and some transition and heavy metal ions. They were employed for direct determination of lead in solder alloys and in galena rocks with a good agreement with the obtained results by atomic absorption spectroscopy. View Full-Text
Keywords: Lead (II); Thiopental; Phenytoin; Galena rocks; Solder alloys Lead (II); Thiopental; Phenytoin; Galena rocks; Solder alloys
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Rizk, N.M.; Abbas, S.S.; Hamza, S.M.; Hamza, S.M.; Abd EL-Karem, Y.M. Thiopental and Phenytoin as Novel Ionophores for Potentiometric Determination of Lead (II) Ions. Sensors 2009, 9, 1860-1875.

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