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Volume 9
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Review

Reporter Proteins in Whole-Cell Optical Bioreporter Detection Systems, Biosensor Integrations, and Biosensing Applications

by
Dan M. Close
,
Steven Ripp
and
Gary S. Sayler
*
The University of Tennessee, The Center for Environmental Biotechnology, 676 Dabney Hall, Knoxville, Tennessee, 37996, USA
*
Author to whom correspondence should be addressed.
Sensors 2009, 9(11), 9147-9174; https://doi.org/10.3390/s91109147
Submission received: 18 September 2009 / Revised: 14 October 2009 / Accepted: 23 October 2009 / Published: 17 November 2009
(This article belongs to the Special Issue Microbial Sensors and Biosensors)
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Abstract

Whole-cell, genetically modified bioreporters are designed to emit detectable signals in response to a target analyte or related group of analytes. When integrated with a transducer capable of measuring those signals, a biosensor results that acts as a self-contained analytical system useful in basic and applied environmental, medical, pharmacological, and agricultural sciences. Historically, these devices have focused on signaling proteins such as green fluorescent protein, aequorin, firefly luciferase, and/or bacterial luciferase. The biochemistry and genetic development of these sensor systems as well as the advantages, challenges, and common applications of each one will be discussed.
Keywords: aequorin; bacterial luciferase (Lux); bioreporter; biosensor; firefly luciferase (Luc); green fluorescent protein (GFP) aequorin; bacterial luciferase (Lux); bioreporter; biosensor; firefly luciferase (Luc); green fluorescent protein (GFP)

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MDPI and ACS Style

Close, D.M.; Ripp, S.; Sayler, G.S. Reporter Proteins in Whole-Cell Optical Bioreporter Detection Systems, Biosensor Integrations, and Biosensing Applications. Sensors 2009, 9, 9147-9174. https://doi.org/10.3390/s91109147

AMA Style

Close DM, Ripp S, Sayler GS. Reporter Proteins in Whole-Cell Optical Bioreporter Detection Systems, Biosensor Integrations, and Biosensing Applications. Sensors. 2009; 9(11):9147-9174. https://doi.org/10.3390/s91109147

Chicago/Turabian Style

Close, Dan M., Steven Ripp, and Gary S. Sayler. 2009. "Reporter Proteins in Whole-Cell Optical Bioreporter Detection Systems, Biosensor Integrations, and Biosensing Applications" Sensors 9, no. 11: 9147-9174. https://doi.org/10.3390/s91109147

APA Style

Close, D. M., Ripp, S., & Sayler, G. S. (2009). Reporter Proteins in Whole-Cell Optical Bioreporter Detection Systems, Biosensor Integrations, and Biosensing Applications. Sensors, 9(11), 9147-9174. https://doi.org/10.3390/s91109147

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