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Sensors 2007, 7(3), 400-409;

A New Tiapride Selective Electrode and Its Clinical Application

Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain
Author to whom correspondence should be addressed.
Received: 29 January 2007 / Accepted: 19 March 2007 / Published: 27 March 2007
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The construction and electrochemical response characteristics of a poly(vinylchloride) (PVC) membrane selective electrode for the determination of tiapride (TPD) are described. The sensing membrane comprised an ion-pair formed between the protonated drug and tetraphenylborate (TPB-) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a wide tiapride concentration range (1x10-5-1x10-2 M) with a slope of 57.5±0.2 mV dec-1 of concentration, a detection limit of 4.3x10-6±2.5x10-7 M, a wide working pH range (2-8) and a fast response time (< 5 s). The electrode showed good selectivity towards tiapride with respect to some inorganic and organic compounds. The electrode has been applied to the determination of tiapride in human urine and iontophoresis solution. View Full-Text
Keywords: Ion-selective electrode; tiapride determination; urine; iontophoresis solution. Ion-selective electrode; tiapride determination; urine; iontophoresis solution.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ortuño, J.A.; Ródenas, V.; García, M.S.; Albero, M.I.; Sánchez-Pedreño, C. A New Tiapride Selective Electrode and Its Clinical Application. Sensors 2007, 7, 400-409.

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