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Review

Recent Advances in Quenchbody, a Fluorescent Immunosensor

by 1,2,3 and 1,2,*
1
Tokyo Tech World Research Hub Initiative (WRHI), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan
2
Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan
3
School of Life Science and Technology, Weifang Medical University, Weifang 261053, China
*
Author to whom correspondence should be addressed.
Academic Editor: Biao Dong
Sensors 2021, 21(4), 1223; https://doi.org/10.3390/s21041223
Received: 26 December 2020 / Revised: 27 January 2021 / Accepted: 6 February 2021 / Published: 9 February 2021
(This article belongs to the Special Issue Fluorescent Sensors)
The detection of viruses, disease biomarkers, physiologically active substances, drugs, and chemicals is of great significance in many areas of our lives. Immunodetection technology is based on the specificity and affinity of antigen–antibody reactions. Compared with other analytical methods such as liquid chromatography coupled with mass spectrometry, which requires a large and expensive instrument, immunodetection has the advantages of simplicity and good selectivity and is thus widely used in disease diagnosis and food/environmental monitoring. Quenchbody (Q-body), a new type of fluorescent immunosensor, is an antibody fragment labeled with fluorescent dyes. When the Q-body binds to its antigen, the fluorescence intensity increases. The detection of antigens by changes in fluorescence intensity is simple, easy to operate, and highly sensitive. This review comprehensively discusses the principle, construction, application, and current progress related to Q-bodies. View Full-Text
Keywords: antibody; immunoassay; fluorescence; quench; detection; biomarker antibody; immunoassay; fluorescence; quench; detection; biomarker
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MDPI and ACS Style

Dong, J.; Ueda, H. Recent Advances in Quenchbody, a Fluorescent Immunosensor. Sensors 2021, 21, 1223. https://doi.org/10.3390/s21041223

AMA Style

Dong J, Ueda H. Recent Advances in Quenchbody, a Fluorescent Immunosensor. Sensors. 2021; 21(4):1223. https://doi.org/10.3390/s21041223

Chicago/Turabian Style

Dong, Jinhua, and Hiroshi Ueda. 2021. "Recent Advances in Quenchbody, a Fluorescent Immunosensor" Sensors 21, no. 4: 1223. https://doi.org/10.3390/s21041223

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