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Graphene-Based Sensor for Detection of Bacterial Pathogens

1
Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Göteborg, Sweden
2
Department of Microtechnology and Nanoscience, Chalmers University of Technology, 412 96 Göteborg, Sweden
3
Novo Nordisk Foundation, Center for Biosustainability, Technical University of Denmark, 2800 Kongens Lyngby, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Vojtěch Adam
Sensors 2021, 21(23), 8085; https://doi.org/10.3390/s21238085
Received: 8 November 2021 / Revised: 24 November 2021 / Accepted: 28 November 2021 / Published: 3 December 2021
(This article belongs to the Section Biosensors)
Microbial colonization to biomedical surfaces and biofilm formation is one of the key challenges in the medical field. Recalcitrant biofilms on such surfaces cause serious infections which are difficult to treat using antimicrobial agents, due to their complex structure. Early detection of microbial colonization and monitoring of biofilm growth could turn the tide by providing timely guidance for treatment or replacement of biomedical devices. Hence, there is a need for sensors, which could generate rapid signals upon bacterial colonization. In this study, we developed a simple prototype sensor based on pristine, non-functionalized graphene. The detection principle is a change in electrical resistance of graphene upon exposure to bacterial cells. Without functionalization with specific receptors, such sensors cannot be expected to be selective to certain bacteria. However, we demonstrated that two different bacterial species can be detected and differentiated by our sensor due to their different growth dynamics, adherence pattern, density of adhered bacteria and microcolonies formation. These distinct behaviors of tested bacteria depicted distinguishable pattern of resistance change, resistance versus gate voltage plot and hysteresis effect. This sensor is simple to fabricate, can easily be miniaturized, and can be effective in cases when precise identification of species is not needed. View Full-Text
Keywords: graphene; sensors; Pseudomonas aeruginosa; Staphylococcus epidermidis; biofilms graphene; sensors; Pseudomonas aeruginosa; Staphylococcus epidermidis; biofilms
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MDPI and ACS Style

Pandit, S.; Li, M.; Chen, Y.; Rahimi, S.; Mokkapati, V.; Merlo, A.; Yurgens, A.; Mijakovic, I. Graphene-Based Sensor for Detection of Bacterial Pathogens. Sensors 2021, 21, 8085. https://doi.org/10.3390/s21238085

AMA Style

Pandit S, Li M, Chen Y, Rahimi S, Mokkapati V, Merlo A, Yurgens A, Mijakovic I. Graphene-Based Sensor for Detection of Bacterial Pathogens. Sensors. 2021; 21(23):8085. https://doi.org/10.3390/s21238085

Chicago/Turabian Style

Pandit, Santosh, Mengyue Li, Yanyan Chen, Shadi Rahimi, Vrss Mokkapati, Alessandra Merlo, August Yurgens, and Ivan Mijakovic. 2021. "Graphene-Based Sensor for Detection of Bacterial Pathogens" Sensors 21, no. 23: 8085. https://doi.org/10.3390/s21238085

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