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Vacuum Ultraviolet Absorption Spectroscopy Analysis of Breath Acetone Using a Hollow Optical Fiber Gas Cell

Graduate School of Biomedical Engineering, Tohoku University, 6-6-05 Aoba, Sendai 980-8579, Japan
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Sensors 2021, 21(2), 478; https://doi.org/10.3390/s21020478
Received: 21 December 2020 / Revised: 6 January 2021 / Accepted: 8 January 2021 / Published: 12 January 2021
(This article belongs to the Section Physical Sensors)
Human breath is a biomarker of body fat metabolism and can be used to diagnose various diseases, such as diabetes. As such, in this paper, a vacuum ultraviolet (VUV) spectroscopy system is proposed to measure the acetone in exhaled human breath. A strong absorption acetone peak at 195 nm is detected using a simple system consisting of a deuterium lamp source, a hollow-core fiber gas cell, and a fiber-coupled compact spectrometer corresponding to the VUV region. The hollow-core fiber functions both as a long-path and an extremely small-volume gas cell; it enables us to sensitively measure the trace components of exhaled breath. For breath analysis, we apply multiple regression analysis using the absorption spectra of oxygen, water, and acetone standard gas as explanatory variables to quantitate the concentration of acetone in breath. Based on human breath, we apply the standard addition method to obtain the measurement accuracy. The results suggest that the standard deviation is 0.074 ppm for healthy human breath with an acetone concentration of around 0.8 ppm and a precision of 0.026 ppm. We also monitor body fat burn based on breath acetone and confirm that breath acetone increases after exercise because it is a volatile byproduct of lipolysis. View Full-Text
Keywords: breath acetone measurement; vacuum ultraviolet spectroscopy; hollow optical fiber breath acetone measurement; vacuum ultraviolet spectroscopy; hollow optical fiber
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MDPI and ACS Style

Kudo, Y.; Kino, S.; Matsuura, Y. Vacuum Ultraviolet Absorption Spectroscopy Analysis of Breath Acetone Using a Hollow Optical Fiber Gas Cell. Sensors 2021, 21, 478. https://doi.org/10.3390/s21020478

AMA Style

Kudo Y, Kino S, Matsuura Y. Vacuum Ultraviolet Absorption Spectroscopy Analysis of Breath Acetone Using a Hollow Optical Fiber Gas Cell. Sensors. 2021; 21(2):478. https://doi.org/10.3390/s21020478

Chicago/Turabian Style

Kudo, Yudai; Kino, Saiko; Matsuura, Yuji. 2021. "Vacuum Ultraviolet Absorption Spectroscopy Analysis of Breath Acetone Using a Hollow Optical Fiber Gas Cell" Sensors 21, no. 2: 478. https://doi.org/10.3390/s21020478

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