Assessing Site Specificity of Osteoarthritic Gait Kinematics with Wearable Sensors and Their Association with Patient Reported Outcome Measures (PROMs): Knee versus Hip Osteoarthritis

There is a great need for quantitative outcomes reflecting the functional status in patients with knee or hip osteoarthritis (OA) to advance the development and investigation of interventions for OA. The purpose of this study was to determine if gait kinematics specific to the disease—i.e., knee versus hip OA—can be identified using wearable sensors and statistical parametric mapping (SPM) and whether disease-related gait deviations are associated with patient reported outcome measures. 113 participants (N = 29 unilateral knee OA; N = 30 unilateral hip OA; N = 54 age-matched asymptomatic persons) completed gait analysis with wearable sensors and the Knee/Hip Osteoarthritis Outcome Score (KOOS/HOOS). Data were analyzed using SPM. Knee and hip kinematics differed between patients with knee OA and patients with hip OA (up to 14°, p < 0.001 for knee and 8°, p = 0.003 for hip kinematics), and differences from controls were more pronounced in the affected than unaffected leg of patients. The observed deviations in ankle, knee and hip kinematic trajectories from controls were associated with KOOS/HOOS in both groups. Capturing gait kinematics using wearables has a large potential for application as outcome in clinical trials and for monitoring treatment success in patients with knee or hip OA and in large cohorts representing a major advancement in research on musculoskeletal diseases. View Full-Text

Keywords: inertial measurement unit; walking; joint motion; gait pattern; function; pain; SPM; HOOS; KOOS

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Nüesch, C.; Ismailidis, P.; Koch, D.; Pagenstert, G.; Ilchmann, T.; Eckardt, A.; Stoffel, K.; Egloff, C.; Mündermann, A. Assessing Site Specificity of Osteoarthritic Gait Kinematics with Wearable Sensors and Their Association with Patient Reported Outcome Measures (PROMs): Knee versus Hip Osteoarthritis. Sensors 2021, 21, 5363. https://doi.org/10.3390/s21165363

AMA Style

Nüesch C, Ismailidis P, Koch D, Pagenstert G, Ilchmann T, Eckardt A, Stoffel K, Egloff C, Mündermann A. Assessing Site Specificity of Osteoarthritic Gait Kinematics with Wearable Sensors and Their Association with Patient Reported Outcome Measures (PROMs): Knee versus Hip Osteoarthritis. Sensors. 2021; 21(16):5363. https://doi.org/10.3390/s21165363

Chicago/Turabian Style

Nüesch, Corina, Petros Ismailidis, David Koch, Geert Pagenstert, Thomas Ilchmann, Anke Eckardt, Karl Stoffel, Christian Egloff, and Annegret Mündermann. 2021. "Assessing Site Specificity of Osteoarthritic Gait Kinematics with Wearable Sensors and Their Association with Patient Reported Outcome Measures (PROMs): Knee versus Hip Osteoarthritis" Sensors 21, no. 16: 5363. https://doi.org/10.3390/s21165363

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Author Biographies

Corina Nüesch

Dr. phil. Corina Nüesch is the Deputy Head of the Functional Biomechanics Laboratory at the Department of Orthopaedics and Traumatology and the Department of Spine Surgery at the University Hospital in Basel. She received her Master of Science in Human Movement Science with a major in Biomechanics from the Federal Institute of Technology (ETH) Zurich, Switzerland in 2008 and her PhD in Biomedical Engineering from the University of Basel, Switzerland in 2013. Her research interests are gait and movement biomechanics of patients suffering from musculoskeletal injuries and diseases such as osteoarthritis. She is a member of the International and German Society of Biomechanics (ISB and DGfB) and the German Society of Clinical Movement Science (GAMMA).

Petros Ismailidis

Dr. Petros Ismailidis is a consultant surgeon at the Department of Orthopaedics and Traumatology at the University Hospital of Basel. He completed his medical studies at the Aristoteles University of Thessaloniki, Greece and his medical dissertation at the University of Zürich, Switzerland. He holds the Swiss board certification for Orthopaedic Surgery (FMH) and has conducted a clinical and research lower limb arthroplasty and reconstruction fellowship at the Orthopaedic Research Institute of Queensland (ORIQL), Australia. His research focuses on the biomechanics of native hip and knee joints, as well as of total hip and total knee replacements and on osteotomies around the knee. He is a member of the Swiss Medical Association (FMH), Swiss Orthopaedics, AO Trauma Surgery, German Society of Biomechanics and ORIQL.

Christian Egloff

PD Dr. med. Christian Egloff is the Head of the Knee Team and Senior Lecturer at the Department of Orthopaedics and Traumatology at the University Hospital Basel, Switzerland. He received his MD from the University of Zurich, Switzerland, and held a postdoctoral research position in Biomechanics and Kinesiology at the University of Calgary, Canada. He further specialized in adult reconstruction of the lower limb at the University of Toronto, Canada. His research focuses on the biomechanical and biological aspects of the development of osteoarthritis, cartilage biology and sports injuries with its clinical implications. He is a member of the Swiss and European Societies of Orthopaedics, the German speaking Society of Arthroscopy (AGA) and a member of the board of the Society of Traumatology and Orthopaedics in Sports (GOTS).

Annegret Mündermann

Prof. Dr. Annegret Mündermann Ph.D. is the Head of the Functional Biomechanics Research Group at the Department of Orthopaedics and Traumatology at the University Hospital Basel and Adjunct Professor in Biomedical Engineering at the University of Basel, Switzerland. She received her PhD in Medical Science/Biomechanics from the University of Calgary, Canada, and has held research and teaching positions at Stanford University (USA), University of Otago (New Zealand) and University of Konstanz (Germany). Her research focuses on the role of biomechanics in the initiation and progression of osteoarthritis, understanding and improving diagnosis and treatment of musculoskeletal injuries and diseases, and in vivo mechanosensitivity of articular cartilage. She is a member of the International and European Societies of Biomechanics (ISB, ESB), Osteoarthritis Research Society International (OARSI), German Society of Clinical Movement Science (GAMMA), and Society of Traumatology and Orthopaedics in Sports (GOTS) and board member of the German Society of Biomechanics (DGfB).

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Assessing Site Specificity of Osteoarthritic Gait Kinematics with Wearable Sensors and Their Association with Patient Reported Outcome Measures (PROMs): Knee versus Hip Osteoarthritis

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