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Open AccessArticle

A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode

1
Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77840, USA
2
Department of Materials Science and Engineering, Texas A&M University, College Station, TX 77840, USA
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(4), 1098; https://doi.org/10.3390/s20041098
Received: 31 December 2019 / Revised: 10 February 2020 / Accepted: 12 February 2020 / Published: 17 February 2020
(This article belongs to the Section Biosensors)
For the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. To lower the cost of glucose sensors, we developed a paper-based electrical sensor with molecularly imprinted glucose recognition sites and demonstrated the determination of various glucose concentrations in bovine blood solutions. The sensing electrode is integrated with molecular recognition sites in the conductive polymer. A calibration graph as a function of glucose concentration in aqueous solution was acquired and matched with a correlation coefficient of 0.989. We also demonstrated the determination of the added glucose concentrations ranging from 2.2 to 11.1 mM in bovine blood samples with a linear correlation coefficient of 0.984. This non-enzymatic glucose sensor has the potential to reduce the health care cost of test strips as well as make glucose sensor test strips more accessible to underserved communities. View Full-Text
Keywords: low cost; enzyme free; paper sensor; molecular imprinting; polyaniline; glucose sensing low cost; enzyme free; paper sensor; molecular imprinting; polyaniline; glucose sensing
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MDPI and ACS Style

Chen, Z.; Wright, C.; Dincel, O.; Chi, T.-Y.; Kameoka, J. A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode. Sensors 2020, 20, 1098. https://doi.org/10.3390/s20041098

AMA Style

Chen Z, Wright C, Dincel O, Chi T-Y, Kameoka J. A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode. Sensors. 2020; 20(4):1098. https://doi.org/10.3390/s20041098

Chicago/Turabian Style

Chen, Zheyuan; Wright, Christopher; Dincel, Onder; Chi, Ting-Yen; Kameoka, Jun. 2020. "A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode" Sensors 20, no. 4: 1098. https://doi.org/10.3390/s20041098

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