Next Article in Journal
A Ratio Model of L1/L2 Norm for Sound Source Identification
Previous Article in Journal
Spatial Modulation and MP-WFRFT-Aided Multi-Beam Wireless Communication Scheme Based On Random Frequency Diverse Array
Previous Article in Special Issue
Model for Wireless Magnetoelastic Strain Sensors
Open AccessArticle

A Novel NiFe2O4/Paper-Based Magnetoelastic Biosensor to Detect Human Serum Albumin

MicroNano System Research Center, Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education and College of Information and Computer, Taiyuan University of Technology, Jinzhong 030600, China
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(18), 5286; https://doi.org/10.3390/s20185286
Received: 31 July 2020 / Revised: 27 August 2020 / Accepted: 2 September 2020 / Published: 16 September 2020
(This article belongs to the Special Issue Magnetoelastic Sensors)
For the first time, a novel NiFe2O4/paper-based magnetoelastic (ME) biosensor was developed for rapid, sensitive, and portable detection of human serum albumin (HSA). Due to the uniquely magnetoelastic effect of NiFe2O4 nanoparticles and the excellent mechanical properties of the paper, the paper-based ME biosensor transforms the surface stress signal induced by the specific binding of HSA and antibody modified on the paper into the electromagnetic signal. The accumulated binding complex generates a compressive stress on the biosensor surface, resulting in a decrease in the biosensor’s static magnetic permeability, which correlates to the HSA concentrations. To improve the sensitivity of the biosensor, the concentration of NiFe2O4 nanofluid and the impregnated numbers of the NiFe2O4 nanofluid-impregnated papers were optimized. The experimental results demonstrated that the biosensor exhibited a linear response to HSA concentrations ranging from 10 μg∙mL−1 to 200 μg∙mL−1, with a detection limit of 0.43 μg∙mL−1, which is significantly lower than the minimal diagnosis limit of microalbuminuria. The NiFe2O4/paper-based ME biosensor is easy to fabricate, and allows the rapid, highly-sensitive, and selective detection of HSA, providing a valuable analytical device for early monitoring and clinical diagnosis of microalbuminuria and nephropathy. This study shows the successful integration of the paper-based biosensor and the ME sensing analytical method will be a highly-sensitive, easy-to-use, disposable, and portable alternative for point-of-care monitoring. View Full-Text
Keywords: cellulose paper; NiFe2O4 nanoparticles; magnetoelastic biosensor; static magnetic permeability cellulose paper; NiFe2O4 nanoparticles; magnetoelastic biosensor; static magnetic permeability
Show Figures

Figure 1

MDPI and ACS Style

Guo, X.; Liu, R.; Li, H.; Wang, J.; Yuan, Z.; Zhang, W.; Sang, S. A Novel NiFe2O4/Paper-Based Magnetoelastic Biosensor to Detect Human Serum Albumin. Sensors 2020, 20, 5286.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop