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Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications

by 1,2,*, 1,2, 3 and 1,2,*
1
Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL 32310, USA
2
National High Magnetic Field Laboratory, Tallahassee, FL 32310, USA
3
American Dental Association Science & Research Institute, Gaithersburg, MD 20899, USA
*
Authors to whom correspondence should be addressed.
Sensors 2020, 20(18), 5095; https://doi.org/10.3390/s20185095
Received: 19 July 2020 / Revised: 16 August 2020 / Accepted: 4 September 2020 / Published: 7 September 2020
(This article belongs to the Section Nanosensors)
Insulator based dielectrophoresis (iDEP) is becoming increasingly important in emerging biomolecular applications, including particle purification, fractionation, and separation. Compared to conventional electrode-based dielectrophoresis (eDEP) techniques, iDEP has been demonstrated to have a higher degree of selectivity of biological samples while also being less biologically intrusive. Over the past two decades, substantial technological advances have been made, enabling iDEP to be applied from micro, to nano and molecular scales. Soft particles, including cell organelles, viruses, proteins, and nucleic acids, have been manipulated using iDEP, enabling the exploration of subnanometer biological interactions. Recent investigations using this technique have demonstrated a wide range of applications, including biomarker screening, protein folding analysis, and molecular sensing. Here, we review current state-of-art research on iDEP systems and highlight potential future work. View Full-Text
Keywords: insulator dielectrophoresis; dielectrophoresis; cell manipulation; biomolecules insulator dielectrophoresis; dielectrophoresis; cell manipulation; biomolecules
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MDPI and ACS Style

Benhal, P.; Quashie, D.; Kim, Y.; Ali, J. Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications. Sensors 2020, 20, 5095. https://doi.org/10.3390/s20185095

AMA Style

Benhal P, Quashie D, Kim Y, Ali J. Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications. Sensors. 2020; 20(18):5095. https://doi.org/10.3390/s20185095

Chicago/Turabian Style

Benhal, Prateek; Quashie, David; Kim, Yoontae; Ali, Jamel. 2020. "Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications" Sensors 20, no. 18: 5095. https://doi.org/10.3390/s20185095

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