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DNA/RNA Electrochemical Biosensing Devices a Future Replacement of PCR Methods for a Fast Epidemic Containment

Departments of Life Sciences, Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, PO Box 653, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
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Sensors 2020, 20(16), 4648; https://doi.org/10.3390/s20164648
Received: 11 July 2020 / Revised: 16 August 2020 / Accepted: 17 August 2020 / Published: 18 August 2020
(This article belongs to the Special Issue Biosensors – Recent Advances and Future Challenges)
Pandemics require a fast and immediate response to contain potential infectious carriers. In the recent 2020 Covid-19 worldwide pandemic, authorities all around the world have failed to identify potential carriers and contain it on time. Hence, a rapid and very sensitive testing method is required. Current diagnostic tools, reverse transcription PCR (RT-PCR) and real-time PCR (qPCR), have its pitfalls for quick pandemic containment such as the requirement for specialized professionals and instrumentation. Versatile electrochemical DNA/RNA sensors are a promising technological alternative for PCR based diagnosis. In an electrochemical DNA sensor, a nucleic acid hybridization event is converted into a quantifiable electrochemical signal. A critical challenge of electrochemical DNA sensors is sensitive detection of a low copy number of DNA/RNA in samples such as is the case for early onset of a disease. Signal amplification approaches are an important tool to overcome this sensitivity issue. In this review, the authors discuss the most recent signal amplification strategies employed in the electrochemical DNA/RNA diagnosis of pathogens. View Full-Text
Keywords: electrochemical DNA sensor; nucleic acid sensor; signal amplification; DNA; RNA; pathogen sensing electrochemical DNA sensor; nucleic acid sensor; signal amplification; DNA; RNA; pathogen sensing
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Santhanam, M.; Algov, I.; Alfonta, L. DNA/RNA Electrochemical Biosensing Devices a Future Replacement of PCR Methods for a Fast Epidemic Containment. Sensors 2020, 20, 4648.

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