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Article

Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice

1
Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium
2
Institute Biomedical Technology, Ghent University, 9000 Ghent, Belgium
3
Department of Cardiology, Ghent University Hospital, 9000 Ghent, Belgium
4
4BRAIN, Department of Head and Skin, Ghent University, 9000 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this article.
Sensors 2020, 20(14), 3867; https://doi.org/10.3390/s20143867
Received: 5 June 2020 / Revised: 5 July 2020 / Accepted: 8 July 2020 / Published: 10 July 2020
(This article belongs to the Special Issue ECG Sensors)
Ambulatory electrocardiography (AECG) is a primary diagnostic tool in patients with potential arrhythmic disorders. To study the pathophysiological mechanisms of arrhythmic disorders, mouse models are widely implemented. The use of a technique similar to AECG for mice is thus of great relevance. We have optimized a protocol which allows qualitative, long-term ECG data recording in conscious, freely moving mice. Automated algorithms were developed to efficiently process the large amount of data and calculate the average heart rate (HR), the mean peak-to-peak interval and heart rate variability (HRV) based on peak detection. Ectopic beats are automatically detected based on aberrant peak intervals. As we have incorporated a multiple lead configuration in our ECG set-up, the nature and origin of the suggested ectopic beats can be analyzed in detail. The protocol and analysis tools presented here are promising tools for studies which require detailed, long-term ECG characterization in mouse models with potential arrhythmic disorders. View Full-Text
Keywords: ambulatory electrocardiography; mouse; peak analysis; tethered ECG ambulatory electrocardiography; mouse; peak analysis; tethered ECG
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MDPI and ACS Style

Steijns, F.; Tóth, M.I.; Demolder, A.; Larsen, L.E.; Desloovere, J.; Renard, M.; Raedt, R.; Segers, P.; De Backer, J.; Sips, P. Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice. Sensors 2020, 20, 3867. https://doi.org/10.3390/s20143867

AMA Style

Steijns F, Tóth MI, Demolder A, Larsen LE, Desloovere J, Renard M, Raedt R, Segers P, De Backer J, Sips P. Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice. Sensors. 2020; 20(14):3867. https://doi.org/10.3390/s20143867

Chicago/Turabian Style

Steijns, Felke, Máté I. Tóth, Anthony Demolder, Lars E. Larsen, Jana Desloovere, Marjolijn Renard, Robrecht Raedt, Patrick Segers, Julie De Backer, and Patrick Sips. 2020. "Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice" Sensors 20, no. 14: 3867. https://doi.org/10.3390/s20143867

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