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Open AccessCommunication

Ion Chromatographic Fingerprinting of STC-1 Cellular Response for Taste Sensing

1
The Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
2
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(5), 1062; https://doi.org/10.3390/s19051062
Received: 30 January 2019 / Revised: 21 February 2019 / Accepted: 26 February 2019 / Published: 2 March 2019
(This article belongs to the Special Issue Electronic Tongues: Recent Strategies and Applications)
Taste sensing is of great importance in both the pharmaceutical and foodstuff industries, and is currently mainly based on human sensory evaluation. Many approaches based on chemical sensors have been proposed, leading to the development of various electronic tongue systems. However, this approach is limited by the applied recognition methods, which do not consider natural receptors. Biorecognition elements such as taste receptor proteins or whole cells can be involved in the development of taste sensing biosensors usually equipped with various electrochemical transducers. Here, we propose a new approach: intestinal secretin tumor cell line (STC-1) chemosensory cells were applied for taste recognition, and their taste-specific cellular response was decoded from ion chromatographic fingerprints with the use of multivariate data processing by partial least squares discriminant analysis (PLS-DA). This approach could be useful for the development of various non-invasive taste sensing assays, as well as for studying taste transduction mechanisms in vitro. View Full-Text
Keywords: taste sensing; bioelectronic tongue; STC-1 cells; ion chromatography; chromatographic fingerprints; PLS-DA taste sensing; bioelectronic tongue; STC-1 cells; ion chromatography; chromatographic fingerprints; PLS-DA
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MDPI and ACS Style

Zabadaj, M.; Szuplewska, A.; Balcerzak, M.; Chudy, M.; Ciosek-Skibińska, P. Ion Chromatographic Fingerprinting of STC-1 Cellular Response for Taste Sensing. Sensors 2019, 19, 1062.

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