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Designing Paper-Based Immunoassays for Biomedical Applications

1
Department of Engineering, University of Massachusetts, Boston, MA 02125, USA
2
Little Devices Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(3), 554; https://doi.org/10.3390/s19030554
Received: 1 December 2018 / Revised: 14 January 2019 / Accepted: 21 January 2019 / Published: 29 January 2019
(This article belongs to the Section Biosensors)
Paper-based sensors and assays have been highly attractive for numerous biological applications, including rapid diagnostics and assays for disease detection, food safety, and clinical care. In particular, the paper immunoassay has helped drive many applications in global health due to its low cost and simplicity of operation. This review is aimed at examining the fundamentals of the technology, as well as different implementations of paper-based assays and discuss novel strategies for improving their sensitivity, performance, or enabling new capabilities. These innovations can be categorized into using unique nanoparticle materials and structures for detection via different techniques, novel biological species for recognizing biomarkers, or innovative device design and/or architecture. View Full-Text
Keywords: paper-based immunoassays; lateral flow assay; biological sensors; dipstick assay; rapid diagnostics paper-based immunoassays; lateral flow assay; biological sensors; dipstick assay; rapid diagnostics
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MDPI and ACS Style

Hristov, D.R.; Rodriguez-Quijada, C.; Gomez-Marquez, J.; Hamad-Schifferli, K. Designing Paper-Based Immunoassays for Biomedical Applications. Sensors 2019, 19, 554. https://doi.org/10.3390/s19030554

AMA Style

Hristov DR, Rodriguez-Quijada C, Gomez-Marquez J, Hamad-Schifferli K. Designing Paper-Based Immunoassays for Biomedical Applications. Sensors. 2019; 19(3):554. https://doi.org/10.3390/s19030554

Chicago/Turabian Style

Hristov, Delyan R.; Rodriguez-Quijada, Cristina; Gomez-Marquez, Jose; Hamad-Schifferli, Kimberly. 2019. "Designing Paper-Based Immunoassays for Biomedical Applications" Sensors 19, no. 3: 554. https://doi.org/10.3390/s19030554

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