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Article

Detection of Cu2+ Ions with GGH Peptide Realized with Si-Nanoribbon ISFET

1
Transport at Nanoscale Interfaces Laboratory, Empa–Swiss Federal Laboratories for Materials Science and Technology, Ueberlandstrasse 129, CH-8600 Duebendorf, Switzerland
2
Department of Physics, University of Basel, Klingelbergstrasse 82, CH-4056 Basel, Switzerland
3
Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904, Israel
*
Authors to whom correspondence should be addressed.
Current affiliation: Max Plank Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany.
Sensors 2019, 19(18), 4022; https://doi.org/10.3390/s19184022
Received: 19 July 2019 / Revised: 29 August 2019 / Accepted: 12 September 2019 / Published: 18 September 2019
(This article belongs to the Special Issue Potentiometric Bio/Chemical Sensing)
The presence of heavy metal ions such as copper in the human body at certain concentrations and specific conditions can lead to the development of different diseases. The currently available analytical detection methods remain expensive, time-consuming, and often require sample pre-treatment. The development of specific and quantitative, easy-in-operation, and cost-effective devices, capable of monitoring the level of Cu2+ ions in environmental and physiological media, is necessary. We use silicon nanoribbon (SiNR) ion-sensitive field effect transistor (ISFET) devices modified with a Gly–Gly–His peptide for the detection of copper ions in a large concentration range. The specific binding of copper ions causes a conformational change of the ligand, and a deprotonation of secondary amine groups. By performing differential measurements, we gain a deeper insight into the details of the ion–ligand interaction. We highlight in particular the importance of considering non-specific interactions to explain the sensors’ response. View Full-Text
Keywords: potentiometric sensing; copper; GGH peptide; ion-sensitive field effect transistor; silicon nanoribbons potentiometric sensing; copper; GGH peptide; ion-sensitive field effect transistor; silicon nanoribbons
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MDPI and ACS Style

Synhaivska, O.; Mermoud, Y.; Baghernejad, M.; Alshanski, I.; Hurevich, M.; Yitzchaik, S.; Wipf, M.; Calame, M. Detection of Cu2+ Ions with GGH Peptide Realized with Si-Nanoribbon ISFET. Sensors 2019, 19, 4022. https://doi.org/10.3390/s19184022

AMA Style

Synhaivska O, Mermoud Y, Baghernejad M, Alshanski I, Hurevich M, Yitzchaik S, Wipf M, Calame M. Detection of Cu2+ Ions with GGH Peptide Realized with Si-Nanoribbon ISFET. Sensors. 2019; 19(18):4022. https://doi.org/10.3390/s19184022

Chicago/Turabian Style

Synhaivska, Olena, Yves Mermoud, Masoud Baghernejad, Israel Alshanski, Mattan Hurevich, Shlomo Yitzchaik, Mathias Wipf, and Michel Calame. 2019. "Detection of Cu2+ Ions with GGH Peptide Realized with Si-Nanoribbon ISFET" Sensors 19, no. 18: 4022. https://doi.org/10.3390/s19184022

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