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Open AccessArticle

3D Simulations of Intracerebral Hemorrhage Detection Using Broadband Microwave Technology

1
Department of Electrical Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden
2
MedTech West, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
3
Inst of Neuroscience and Physiology, Dept. of Clinical Neurophysiology, Sahlgrenska Academy, Göteborg University and with Neuro-Division, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(16), 3482; https://doi.org/10.3390/s19163482
Received: 13 May 2019 / Revised: 1 August 2019 / Accepted: 6 August 2019 / Published: 9 August 2019
(This article belongs to the Special Issue Microwave Sensors for Biomedical Applications)
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Abstract

Early, preferably prehospital, detection of intracranial bleeding after trauma or stroke would dramatically improve the acute care of these large patient groups. In this paper, we use simulated microwave transmission data to investigate the performance of a machine learning classification algorithm based on subspace distances for the detection of intracranial bleeding. A computational model, consisting of realistic human head models of patients with bleeding, as well as healthy subjects, was inserted in an antenna array model. The Finite-Difference Time-Domain (FDTD) method was then used to generate simulated transmission coefficients between all possible combinations of antenna pairs. These transmission data were used both to train and evaluate the performance of the classification algorithm and to investigate its ability to distinguish patients with versus without intracranial bleeding. We studied how classification results were affected by the number of healthy subjects and patients used to train the algorithm, and in particular, we were interested in investigating how many samples were needed in the training dataset to obtain classification results better than chance. Our results indicated that at least 200 subjects, i.e., 100 each of the healthy subjects and bleeding patients, were needed to obtain classification results consistently better than chance (p < 0.05 using Student’s t-test). The results also showed that classification results improved with the number of subjects in the training data. With a sample size that approached 1000 subjects, classifications results characterized as area under the receiver operating curve (AUC) approached 1.0, indicating very high sensitivity and specificity. View Full-Text
Keywords: intracranial hemorrhage; stroke; machine learning; subspace classifier; microwave technology; FDTD modeling intracranial hemorrhage; stroke; machine learning; subspace classifier; microwave technology; FDTD modeling
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Fhager, A.; Candefjord, S.; Elam, M.; Persson, M. 3D Simulations of Intracerebral Hemorrhage Detection Using Broadband Microwave Technology. Sensors 2019, 19, 3482.

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