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Open AccessFeature PaperArticle

Simultaneous Voltammetric Determination of Acetaminophen, Ascorbic Acid and Uric Acid by Use of Integrated Array of Screen-Printed Electrodes and Chemometric Tools

Sensors and Biosensors Group, Department of Chemistry, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
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Sensors 2019, 19(15), 3286; https://doi.org/10.3390/s19153286
Received: 28 June 2019 / Revised: 19 July 2019 / Accepted: 24 July 2019 / Published: 26 July 2019
(This article belongs to the Special Issue Biomimetic Sensor Arrays)
In the present work, ternary mixtures of Acetaminophen, Ascorbic acid and Uric acid were resolved using the Electronic tongue (ET) principle and Cyclic voltammetry (CV) technique. The screen-printed integrated electrode array having differentiated response for the three oxidizable compounds was formed by Graphite, Prussian blue (PB), Cobalt (II) phthalocyanine (CoPc) and Copper oxide (II) (CuO) ink-modified carbon electrodes. A set of samples, ranging from 0 to 500 µmol·L−1, was prepared, using a tilted (33) factorial design in order to build the quantitative response model. Subsequently, the model performance was evaluated with an external subset of samples defined randomly along the experimental domain. Partial Least Squares Regression (PLS) was employed to construct the quantitative model. Finally, the model successfully predicted the concentration of the three compounds with a normalized root mean square error (NRMSE) of 1.00 and 0.99 for the training and test subsets, respectively, and R2 ≥ 0.762 for the obtained vs. expected comparison graphs. In this way, a screen-printed integrated electrode platform can be successfully used for voltammetric ET applications. View Full-Text
Keywords: electronic tongue; modifiers; acetaminophen; ascorbic acid; uric acid; partial least squares regression electronic tongue; modifiers; acetaminophen; ascorbic acid; uric acid; partial least squares regression
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MDPI and ACS Style

Ortiz-Aguayo, D.; Bonet-San-Emeterio, M.; del Valle, M. Simultaneous Voltammetric Determination of Acetaminophen, Ascorbic Acid and Uric Acid by Use of Integrated Array of Screen-Printed Electrodes and Chemometric Tools. Sensors 2019, 19, 3286.

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