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Open AccessArticle

Direct Detection of Candida albicans with a Membrane Based Electrochemical Impedance Spectroscopy Sensor

1
Department of Micro- and Nanotechnology, Technical University of Denmark, rsteds Plads, Building 345 B, 2800 Kgs. Lyngby, Denmark
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Department of Haematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Sensors 2018, 18(7), 2214; https://doi.org/10.3390/s18072214
Received: 24 May 2018 / Revised: 25 June 2018 / Accepted: 6 July 2018 / Published: 10 July 2018
(This article belongs to the Section Biosensors)
Candidemia and invasive candidiasis is a cause of high mortality and morbidity rates among hospitalized patients worldwide. The occurrence of the infections increases due to the complexity of the patients and overuse of the antifungal therapy. The current Candida detection method includes blood culturing which is a lengthy procedure and thus delays the administration of the antifungal therapy. Even though the results are available after 48 h it is still the gold standard in pathogen detection in a hospital setting. In this work we present an electrochemical impedance sensor that is capable of detecting Candida albicans yeast. The yeast cells are captured on electrodes specifically functionalized with anti-Candida antibodies and detection is achieved by electrochemical impedance spectroscopy. The sensor allows for detection of the yeast cells at clinically relevant concentrations in less than 1 h. View Full-Text
Keywords: Candida; electrochemical impedance spectroscopy; membrane based sensor Candida; electrochemical impedance spectroscopy; membrane based sensor
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Kwasny, D.; Tehrani, S.E.; Almeida, C.; Schjødt, I.; Dimaki, M.; Svendsen, W.E. Direct Detection of Candida albicans with a Membrane Based Electrochemical Impedance Spectroscopy Sensor. Sensors 2018, 18, 2214.

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